SARS-CoV-2 infection in asymptomatic healthcare workers at a clinic in Chile

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dc.contributor.authorOlmos, Claudio
dc.contributor.authorCampaña, Gonzalo
dc.contributor.authorMonreal, Victor
dc.contributor.authorPidal, Paola
dc.contributor.authorSanchez, Nannet
dc.contributor.authorAirola, Constanza
dc.contributor.authorSanhueza, Dayan
dc.contributor.authorTapia, Patricio
dc.contributor.authorMuñoz, Ana María
dc.contributor.authorCorvalan, Felipe
dc.contributor.authorMeneses, Claudio
dc.contributor.authorOrellana, Ariel
dc.contributor.authorMontecino, Martin
dc.contributor.authorArriagada, Gloria
dc.contributor.authorBustos, Fernando Jose
dc.date.accessioned2022-06-03T21:51:05Z
dc.date.available2022-06-03T21:51:05Z
dc.date.issued2021-01
dc.descriptionIndexación Scopuses
dc.description.abstractAsymptomatic SARS-CoV-2 infection of healthcare workers (HCWs) has been reported as a key player in the nosocomial spreading of COVID-19. Early detection of infected HCWs can prevent spreading of the virus in hospitals among HCWs and patients. We conducted a cross-sectional study to determine the asymptomatic infection of HCWs in a private clinic in the city of Santiago, Chile. Our study was conducted during a period of 5 weeks at the peak of transmission of SARS-CoV-2 in Chile. Nasopharyngeal samples were obtained from 413 HCWs and tested for the presence of SARS-CoV-2 using RT-qPCR. We found that a 3.14% of HCWs were positive for the presence of SARS-CoV-2 (14/413). Out of these, 7/14 were completely asymptomatic and did not develop symptoms within 3 weeks of testing. Sequencing of viral genomes showed the predominance of the GR clade; however, sequence comparison demonstrated numerous genetic differences among them suggesting community infection as the main focus of transmission among HCWs. Our study demonstrates that the protocols applied to protect HCWs and patients have been effective as no infection clusters due to asymptomatic carriers were found in the clinic. Together, these data suggest that infection with SARS-CoV-2 among HCWs of this health center is not nosocomial. © 2021 Olmos et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.es
dc.identifier.citationPLoS ONE Volume 16, Issue 1 January January 2021 Article number e0245913es
dc.identifier.doi10.1371/journal.pone.0245913
dc.identifier.issn1932-6203
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/22714
dc.language.isoenes
dc.publisherPublic Library of Sciencees
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAdultes
dc.subjectAsymptomatices
dc.subjectChilees
dc.subjectCOVID-19es
dc.subjectCross-Sectional Studieses
dc.subjectFemalees
dc.subjectHealth Personneles
dc.subjectHospitals, Universityes
dc.subjectHumanses
dc.subjectInfection Controles
dc.subjectMalees
dc.subjectMiddle Agedes
dc.subjectSARS-CoV-2es
dc.titleSARS-CoV-2 infection in asymptomatic healthcare workers at a clinic in Chilees
dc.typeArtículoes
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