Angiotensin-(1-7) Prevents Skeletal Muscle Atrophy Induced by Transforming Growth Factor Type Beta (TGF-β) via Mas Receptor Activation

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dc.contributor.authorAbrigo, J
dc.contributor.authorSimon, F
dc.contributor.authorCabrera, D
dc.contributor.authorCabello-Verrugio, C
dc.date.accessioned2017-04-28T20:23:01Z
dc.date.available2017-04-28T20:23:01Z
dc.date.issued2016
dc.descriptionIndexación: Web of Science; Scielo.es
dc.description.abstractBackground: Transforming growth factor type beta 1 (TGF-131) produces skeletal muscle atrophy. Angiotensin-(1-7) (Ang-(1-7)), through the Mas receptor, prevents the skeletal muscle atrophy induced by sepsis, immobilization, or angiotensin II (Ang-II). However, the effect of Ang(1-7) on muscle wasting induced by TGF-beta 1 is unknown. Aim: To evaluate whether Ang-(1-7)/Mas receptor axis could prevent the skeletal muscle atrophy induced by TGF-131. Methods: This study assessed the atrophic effect of TGF-beta 1 in C2C12, myotubes and mice in absence or presence of Ang-(1-7), and the receptor participation using A779, an antagonist of the Mas receptor. The levels of myosin heavy chain (MHC), polyubiquitination, and MuRF-1 were detected by western blot. Myotube diameter was also evaluated. In vivo analysis included the muscle strength, fibre diameter, MHC and MuRF-1 levels by western blot, and ROS levels by DCF probe detection. Results: The results showed that Ang-(1-7) prevented the increase in MuRF-1 and polyubiquitined protein levels, the decrease of MHC levels, the myotubes/ fibre diameter diminution, and the increased production of reactive oxygen species (ROS) induced by TGF-beta 1. Utilizing A779 inhibited the anti-atrophic effect of Ang-(1-7). Conclusion: The preventive effect of Ang-(1-7) on skeletal muscle atrophy induced by TGF-beta 1 is produced through inhibition of ROS production and proteasomal degradation of MHC. (C) 2016 The Author(s) Published by S Karger AG, Baseles
dc.description.urihttps://www.karger.com/Article/FullText/452522
dc.identifier.citationCell Physiol Biochem 2016;40:27-38es
dc.identifier.issn1015-8987
dc.identifier.otherDOI: 10.1159/000452522
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/3363
dc.language.isoenes
dc.publisherKARGERes
dc.subjectMuscle wastinges
dc.subjectTGF-betaes
dc.subjectng-(1-7)es
dc.subjectMas receptores
dc.subjectMHCes
dc.subjectMuRF-1es
dc.titleAngiotensin-(1-7) Prevents Skeletal Muscle Atrophy Induced by Transforming Growth Factor Type Beta (TGF-β) via Mas Receptor Activationes
dc.typeArtículoes
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