NEDD4-1 deficiency impairs satellite cell function during skeletal muscle regeneration

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dc.contributor.authorCabezas, Felipe
dc.contributor.authorCabello-Verrugio, Claudio
dc.contributor.authorGonzález, Natalia
dc.contributor.authorSalas, Jeremy
dc.contributor.authorRamírez, Manuel J.
dc.contributor.authorDe la Vega, Eduardo
dc.contributor.authorOlguín, Hugo C.
dc.date.accessioned2023-07-14T22:57:01Z
dc.date.available2023-07-14T22:57:01Z
dc.date.issued2023-05
dc.descriptionIndexación: Scopuses
dc.description.abstractBackground: Satellite cells are tissue-specific stem cells primarily responsible for the regenerative capacity of skeletal muscle. Satellite cell function and maintenance are regulated by extrinsic and intrinsic mechanisms, including the ubiquitin–proteasome system, which is key for maintaining protein homeostasis. In this context, it has been shown that ubiquitin-ligase NEDD4-1 targets the transcription factor PAX7 for proteasome-dependent degradation, promoting muscle differentiation in vitro. Nonetheless, whether NEDD4-1 is required for satellite cell function in regenerating muscle remains to be determined. Results: Using conditional gene ablation, we show that NEDD4-1 loss, specifically in the satellite cell population, impairs muscle regeneration resulting in a significant reduction of whole-muscle size. At the cellular level, NEDD4-1-null muscle progenitors exhibit a significant decrease in the ability to proliferate and differentiate, contributing to the formation of myofibers with reduced diameter. Conclusions: These results indicate that NEDD4-1 expression is critical for proper muscle regeneration in vivo and suggest that it may control satellite cell function at multiple levels. © 2023, The Author(s).es
dc.description.urihttps://biolres.biomedcentral.com/articles/10.1186/s40659-023-00432-7
dc.identifier.citationBiological Research Volume 56, Issue 1May 2023 Article number 21es
dc.identifier.doi10.1186/s40659-023-00432-7
dc.identifier.issn0716-9760
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/51673
dc.language.isoenes
dc.publisherBioMed Central Ltd.es
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectMuscle differentiationes
dc.subjectMuscle stem cellses
dc.subjectNEDD4-1es
dc.subjectSatellite cellses
dc.subjectSkeletal muscle regenerationes
dc.titleNEDD4-1 deficiency impairs satellite cell function during skeletal muscle regenerationes
dc.typeArtículoes
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