The product of the qacC gene of Staphylococcus epidermidis CH mediates resistance to β-lactam antibiotics in Gram-positive and Gram-negative bacteria

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dc.contributor.authorFuentes, DE
dc.contributor.authorNavarro, CA
dc.contributor.authorTantaleán, JC
dc.contributor.authorAraya, MA
dc.contributor.authorSaavedra, CP
dc.contributor.authorPérez, JM
dc.contributor.authorCalderón, IL
dc.contributor.authorYouderian, PA
dc.contributor.authorMora, GC
dc.contributor.authorVásquez, CC
dc.date.accessioned2024-07-03T18:45:26Z
dc.date.available2024-07-03T18:45:26Z
dc.date.issued2005-05-01
dc.descriptionINDEXACIÓN: WEB OF SCIENCE.
dc.description.abstractWe have characterized a natural isolate of Staphylococcus epidermidis resistant to heavy metals that carries a small 2391-bp plasmid, pSepCH, encoding the qacC gene. The S. epidermidis qacC gene confers resistance to a number of beta-lactam antibiotics and to ethidium bromide in its natural host and in Escherichia coli K12 and Salmonella enterica sv. Typhimurium. This is the first communication of a small multidrug resistance (SMR) pump involved in resistance to beta-lactam antibiotics. Experiments using tolC, ompW and ompD mutant strains of S. Typhimurium demonstrated that the beta-lactam antibiotic resistance conferred by this pump does not depend on these outer membrane proteins. (c) 2005 Elsevier SAS. All rights reserved.
dc.identifier.citationRESEARCH IN MICROBIOLOGY, Volume 156, Issue 4, Page, 472-477
dc.identifier.doi10.1016/j.resmic.2005.01.002
dc.identifier.issn0923-2508
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/58181
dc.language.isoen
dc.publisherElsevier
dc.rights.licenseCC BY-NC-ND 4.0 ATRIBUCIÓN-NOCOMERCIAL-SINDERIVADAS 4.0 INTERNACIONAL Deed
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subjectmultidrug resistance
dc.subjectStaphylococcus epidermidis
dc.subjectbeta-lactam resistance
dc.subjectethidium bromide
dc.subjectSMR
dc.titleThe product of the qacC gene of Staphylococcus epidermidis CH mediates resistance to β-lactam antibiotics in Gram-positive and Gram-negative bacteria
dc.typeArtículo
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