IRE1α activation in bone marrow-derived dendritic cells modulates innate recognition of melanoma cells and favors CD8+ T cell priming

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dc.contributor.authorMedel, Bernardita
dc.contributor.authorCostoya, Cristobal
dc.contributor.authorFernandez, Dominique
dc.contributor.authorPereda, Cristian
dc.contributor.authorLladser, Alvaro
dc.contributor.authorSauma, Daniela
dc.contributor.authorPacheco, Rodrigo
dc.contributor.authorIwawaki, Takao
dc.contributor.authorSalazar Onfray, Flavio
dc.contributor.authorOsorio, Fabiola
dc.date.accessioned2022-07-14T16:29:52Z
dc.date.available2022-07-14T16:29:52Z
dc.date.issued2019-01
dc.descriptionIndexación: Scopuses
dc.description.abstractThe IRE1α/XBP1s signaling pathway is an arm of the unfolded protein response (UPR) that safeguards the fidelity of the cellular proteome during endoplasmic reticulum (ER) stress, and that has also emerged as a key regulator of dendritic cell (DC) homeostasis. However, in the context of DC activation, the regulation of the IRE1α/XBP1s axis is not fully understood. In this work, we report that cell lysates generated from melanoma cell lines markedly induce XBP1s and certain members of the UPR such as the chaperone BiP in bone marrow derived DCs (BMDCs). Activation of IRE1α endonuclease upon innate recognition of melanoma cell lysates was required for amplification of proinflammatory cytokine production and was necessary for efficient cross-presentation of melanoma-associated antigens without modulating the MHC-II antigen presentation machinery. Altogether, this work provides evidence indicating that ex-vivo activation of the IRE1α/XBP1 pathway in BMDCs enhances CD8+ T cell specific responses against tumor antigens. © 2007 - 2019 Frontiers Media S.A. All Rights Reserved.es
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fimmu.2018.03050/full
dc.identifier.citationFrontiers in Immunology Volume 10, Issue JAN2019 Article number 3050es
dc.identifier.doi10.3389/fimmu.2018.03050
dc.identifier.issn1664-3224
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/23234
dc.language.isoenes
dc.publisherFrontiers Media S.A.es
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectCross-presentationes
dc.subjectDendritic celles
dc.subjectIRE1αes
dc.subjectMelanomaes
dc.subjectUPRes
dc.subjectXBP1ses
dc.titleIRE1α activation in bone marrow-derived dendritic cells modulates innate recognition of melanoma cells and favors CD8+ T cell priminges
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