Gestational hypothyroxinemia affects its offspring with a reduced suppressive capacity impairing the outcome of the experimental autoimmune encephalomyelitis

Vista sencilla de ítem
dc.contributor.authorHaensgen, H.
dc.contributor.authorAlbornoz, E.
dc.contributor.authorOpazo, M.C.
dc.contributor.authorBugueño, K.
dc.contributor.authorJara Fernández, E.L.
dc.contributor.authorBinzberger, R.
dc.contributor.authorRivero-Castillo, T.
dc.contributor.authorVenegas Salas, L.F.
dc.contributor.authorSimon, F.
dc.contributor.authorCabello-Verrugio, C.
dc.contributor.authorElorza, A.A.
dc.contributor.authorKalergis, A.M.
dc.contributor.authorBueno, S.M.
dc.contributor.authorRiedel, C.A.
dc.date.accessioned2019-05-29T16:28:43Z
dc.date.available2019-05-29T16:28:43Z
dc.date.issued2018-06
dc.descriptionIndexación: Scopus.es_ES
dc.description.abstractHypothyroxinemia (Hpx) is a thyroid hormone deficiency (THD) condition highly frequent during pregnancy, which although asymptomatic for the mother, it can impair the cognitive function of the offspring. Previous studies have shown that maternal hypothyroidism increases the severity of experimental autoimmune encephalomyelitis (EAE), an autoimmune disease model for multiple sclerosis (MS). Here, we analyzed the immune response after EAE induction in the adult offspring gestated in Hpx. Mice gestated in Hpx showed an early appearance of EAE symptoms and the increase of all parameters of the disease such as: the pathological score, spinal cord demyelination, and immune cell infiltration in comparison to the adult offspring gestated in euthyroidism. Isolated CD4+CD25+ T cells from spleen of the offspring gestated in Hpx that suffer EAE showed reduced capacity to suppress proliferation of effector T cells (TEff) after being stimulated with anti-CD3 and anti-CD28 antibodies. Moreover, adoptive transfer experiments of CD4+CD25+ T cells from the offspring gestated in Hpx suffering EAE to mice that were induced with EAE showed that the receptor mice suffer more intense EAE pathological score. Even though, no significant differences were detected in the frequency of Treg cells and IL-10 content in the blood, spleen, and brain between mice gestated in Hpx or euthyroidism, T cells CD4+CD25+ from spleen have reduced capacity to differentiate in vitro to Treg and to produce IL-10. Thus, our data support the notion that maternal Hpx can imprint the immune response of the offspring suffering EAE probably due to a reduced capacity to trigger suppression. Such "imprints" on the immune system could contribute to explaining as to why adult offspring gestated in Hpx suffer earlier and more intense EAE. © 2018 Haensgen, Albornoz, Opazo, Bugueño, Jara Fernández, Binzberger, Rivero-Castillo, Venegas Salas, Simon, Cabello-Verrugio, Elorza, Kalergis, Bueno and Riedel.es_ES
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fimmu.2018.01257/full
dc.identifier.citationFrontiers in Immunology, 9(JUN), art. no. 1257.es_ES
dc.identifier.issn1664-3224
dc.identifier.otherDOI: 10.3389/fimmu.2018.01257
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/8966
dc.language.isoenes_ES
dc.publisherFrontiers Mediaes_ES
dc.subjectExperimental autoimmune encephalomyelitises_ES
dc.subjectHypothyroxinemiaes_ES
dc.subjectMultiple sclerosises_ES
dc.subjectPregnancyes_ES
dc.subjectT regulatory cellses_ES
dc.titleGestational hypothyroxinemia affects its offspring with a reduced suppressive capacity impairing the outcome of the experimental autoimmune encephalomyelitises_ES
dc.typeArtículoes_ES
Archivos
Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
Haensgen_Gestational.pdf
Tamaño:
1.9 MB
Formato:
Adobe Portable Document Format
Descripción:
TEXTO COMPLETO EN INGLES
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
Fac.CV - Artículos de Revista