Epithelial control of the human pDC response to extracellular bacteria

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dc.contributor.authorMichea, Paula
dc.contributor.authorVargas, Pablo
dc.contributor.authorDonnadieu, Marie-Hélène
dc.contributor.authorRosemblatt, Mario
dc.contributor.authorBono, María Rosa
dc.contributor.authorDuménil, Guillaume
dc.contributor.authorSoumelis, Vassili
dc.date.accessioned2025-05-16T15:06:39Z
dc.date.available2025-05-16T15:06:39Z
dc.date.issued2013-04
dc.descriptionIndexación: Scopus
dc.description.abstractPlasmacytoid pre-dendritic cells (pDCs) are specialized in responding to nucleic acids, and link innate with adaptive immunity. Although the response of pDCs to viruses is well established, whether pDCs can respond to extracellular bacteria remains controversial. Here, we demonstrate that extracellular bacteria such as Neisseria meningitidis, Haemophilus influenzae, and Staphylococcus aureus activate pDCs to produce IFN-α, TNF-α, IL-6, and to upregulate CD86 expression. We observed that pDCs were present within tonsillar crypts and oro-nasopharyngeal epithelium, where they may contact extracellular bacteria, in situ. Tonsil epithelium-conditioned supernatants inhibited IFN-α, TNF-α, and IL-6 triggered by the direct contact of N. meningitidis or S. aureus with pDCs. However, pDC priming of naive T cells was not affected, suggesting that tonsil epithelium micro-environment limits local inflammation while preserving adaptive immunity in response to extracellular bacteria. Our results reveal an important and novel function of pDCs in the initiation of the mucosal innate and adaptive immunity to extracellular bacteria. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
dc.description.accesoabiertoSí
dc.description.agradThis work was supported by grants from International Cooperation Inserm-Conicyt 2009/2011, Conicyt Doctoral Fellowship, Conicyt PFB-16, Université Paris-5 René Descartes Mobility fellowship, Agence Nationale de la Recherche (ANR), and Fondation pour le Recherche Médicale (FRM).
dc.description.urihttps://onlinelibrary-wiley-com.recursosbiblioteca.unab.cl/journal/15214141
dc.identifier.citationEuropean Journal of Immunology. Volume 43, Issue 5, Pages 1264 - 1273. April 2013
dc.identifier.doi10.1002/eji.201242990
dc.identifier.folioInternational Cooperation Inserm-Conicyt 2009/2011
dc.identifier.folioConicyt Doctoral Fellowship, Conicyt PFB-16
dc.identifier.generoM
dc.identifier.issn1521-4141
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/64725
dc.language.isoen
dc.subjectCytokines
dc.subjectExtracellular Bacteria
dc.subjectHuman Mucosa
dc.subjectInnate Immunity
dc.subjectPlasmacytoid pre-dendritic cell
dc.titleEpithelial control of the human pDC response to extracellular bacteria
dc.typeArtículo
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