The ArcAB two-component regulatory system promotes resistance to reactive oxygen species and systemic infection by Salmonella Typhimurium

Vista sencilla de ítem
dc.contributor.authorPardo-Esté, C.
dc.contributor.authorHidalgo, A.A.
dc.contributor.authorAguirre, C.
dc.contributor.authorInostroza, A.
dc.contributor.authorBriones, A.C.
dc.contributor.authorCabezas, C.E.
dc.contributor.authorCastro-Severyn, J.
dc.contributor.authorFuentes, J.A.
dc.contributor.authorOpazo, C.M.
dc.contributor.authorRiedel, C.A.
dc.contributor.authorOtero, C.
dc.contributor.authorPacheco, R.
dc.contributor.authorValvano, M.A.
dc.contributor.authorSaavedra, C.P.
dc.date.accessioned2019-12-03T14:51:53Z
dc.date.available2019-12-03T14:51:53Z
dc.date.issued2018-09
dc.descriptionIndexación: Scopus.es
dc.descriptionFunding:Thisworkwassupportedby"Fondo NacionaldeCienciayTecnologia"FONDECYT Grants#1120384and#1160315(toCPS),Grant PFB-16(toRP)from"Comisio ´nNacionalde Investigacio ´ n Cientı ´ fica y Tecnolo ´ gica de Chile" (CONICYT)andUniversidadAndresBelloNucleo GrantDI-3-17/N(toCPS),andDoctoral
dc.description.abstractSalmonella enterica Serovar Typhimurium (S. Typhimurium) is an intracellular bacterium that overcomes host immune system barriers for successful infection. The bacterium colonizes the proximal small intestine, penetrates the epithelial layer, and is engulfed by macrophages and neutrophils. Intracellularly, S. Typhimurium encounters highly toxic reactive oxygen species including hydrogen peroxide and hypochlorous acid. The molecular mechanisms of Salmonella resistance to intracellular oxidative stress is not completely understood. The ArcAB two-component system is a global regulatory system that responds to oxygen. In this work, we show that the ArcA response regulator participates in Salmonella adaptation to changing oxygen levels and is also involved in promoting intracellular survival in macrophages and neutrophils, enabling S. Typhimurium to successfully establish a systemic infection. © 2018 Pardo-Esté et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.es
dc.description.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203497
dc.identifier.citationPLoS ONE, 13(9), art. no. e0203497.es
dc.identifier.issn1932-6203
dc.identifier.otherDOI: 10.1371/journal.pone.0203497
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/11020
dc.language.isoenes
dc.publisherPublic Library of Sciencees
dc.subjectAerobic respiration control protein Aes
dc.subjectOxygenes
dc.subjectProtein ArcBes
dc.subjectProtein histidine kinasees
dc.subjectReactive oxygen metabolitees
dc.subjectUnclassified druges
dc.subjectBacterial proteines
dc.subjectReactive oxygen metabolitees
dc.titleThe ArcAB two-component regulatory system promotes resistance to reactive oxygen species and systemic infection by Salmonella Typhimuriumes
dc.typeArtículoes
Archivos
Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
Pardo-Este_The_ArcAB_two-component.pdf
Tamaño:
250.11 KB
Formato:
Adobe Portable Document Format
Descripción:
TEXTO COMPLETO EN INGLES
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
Fac.CV - Artículos de Revista