Galectin-3 levels in patients hospitalized for decompensated heart failure

Vista sencilla de ítem
dc.contributor.authorRossel, Víctor
dc.contributor.authorDíaz-Toro, Felipe
dc.contributor.authorVerdejo, Hugo
dc.contributor.authorConcepción, Roberto
dc.contributor.authorSepúlveda, Luis
dc.contributor.authorCastro, Pablo
dc.contributor.authorVukasovic, José Luis
dc.contributor.authorBernales, Angie
dc.date.accessioned2024-09-04T15:23:49Z
dc.date.available2024-09-04T15:23:49Z
dc.date.issued2017
dc.descriptionIndexación: Scopus
dc.description.abstractBackground: Galectin-3 (Gal-3) is a mediator of myocardial fibrosis involved in cardiac remodeling and a potential new prognosis marker in heart failure (HF). Aim: To measure Gal-3 at the moment of discharge in patients hospitalized for HF and its association with different variables. Material and Methods: Patients hospitalized for decompensated HF from four hospitals between August 2014 and March 2015, were included. Demographic, clinical and laboratory variables were recorded at the time of admission. At discharge, a blood sample was withdrawn to measure Gal-3 and brain natriuretic propeptide (Pro-BNP). Patients were separated in two groups, according to the level of Gal-3 (using a cutoff value of 17.8 ng/mL), comparing clinical and laboratory values between groups. Results: We included 52 patients with HF aged 70 ± 17 years (42% females). Functional capacity was III-IV in 46% of patients and the ejection fraction was 34.9 ± 13.4%. Pro-BNP values at discharge were 5,323 ± 8,665 pg/mL. Gal-3 values were 23.8 ± 16.6 ng/mL. Sixty percent of patients had values over 17.8 ng/mL. Those with elevated Gal-3 levels were older (75 ± 16 and 62 ± 15 years,respectively, p = 0.025) and were hypertensive in a higher proportion (90.5% and 57.1% respectively, p = 0.021). Conclusions: In patients hospitalized for HF, Gal-3 levels are higher in older and hypertensive subjects. © 2017, Sociedad Medica de Santiago. All rights reserved.
dc.description.urihttps://www-scielo-cl.recursosbiblioteca.unab.cl/scielo.php?script=sci_arttext&pid=S0034-98872017000600734&lng=en&nrm=iso&tlng=en
dc.identifier.citationRevista Medica de Chile Volume 145, Issue 6, Pages 734 - 7402017
dc.identifier.doi10.4067/s0034-98872017000600734
dc.identifier.issn0034-9887
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/59787
dc.language.isoen
dc.publisherSociedad Medica de Santiago
dc.rights.licenseAtribución/Reconocimiento 4.0 Internacional CC BY 4.0 Deed
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectBiomarkers
dc.subjectGalectin-3
dc.subjectHeart failure
dc.titleGalectin-3 levels in patients hospitalized for decompensated heart failure
dc.title.alternativeGalectina-3: Experiencia en pacientes Chilenos con diagnóstico de insuficiencia cardíaca descompensada
dc.typeArtículo
Archivos
Bloque original
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
TEXTO EN INGLES
Tamaño:
296.95 KB
Formato:
Adobe Portable Document Format
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
FM - Artículos de Revista