Solubilization of phenols by multimolecular aggregates formed by low molecular weight hyperbranched polyglycidol

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dc.contributor.authorOlea, Andres F.
dc.contributor.authorAcevedo, Betsabe
dc.contributor.authorOssandon, Luis
dc.contributor.authorWorrall, David
dc.date.accessioned2024-04-17T15:02:15Z
dc.date.available2024-04-17T15:02:15Z
dc.date.issued2017-08
dc.descriptionIndexación: Scopus
dc.description.abstractHyperbranched polymers have been proposed as potential carriers or host compartments for controlled drug delivery. In this work the solubilization of alkylphenols into aggregates formed by hyperbranched polyglycidol HPG and its ester derivative has been studied. HPG17 was synthesized by ring-opening polymerization of glycidol, and then the ester HPG4-RBr13 has been obtained by reaction of hPG17 with 2-bromo isobutyryl bromide. The critical aggregate concentration CAC and micropolarity of aggregates were determined by using pyrene as fluorescence probe. CAC values obtained are 2.5 mM and 0.25 mM, for HPG17 and HPG4-RBr13, respectively. Our results indicate that the hydrophobic effect is larger for HPG4-RBr13, and that their aggregates are more hydrophobic, than for HPG17. In addition, their sizes and sizes distribution were determined by DLS. The partition of phenols between the micellar and aqueous phase was studied by using the pseudo-phase model, and the results show that the partition coefficients increases with increasing length of the side alkyl chain, and are larger for HPG4-RBr13 micelles than for HPG17 micelles. © 2017 Elsevier B.V.
dc.description.urihttps://www-sciencedirect-com.recursosbiblioteca.unab.cl/science/article/pii/S0927775717301668?via%3Dihub
dc.identifier.citationColloids and Surfaces A: Physicochemical and Engineering Aspects Volume 526, Pages 1 - 75 August 2017
dc.identifier.doi10.1016/j.colsurfa.2017.02.032
dc.identifier.issn0927-7757
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/56061
dc.language.isoen
dc.publisherElsevier B.V.
dc.rights.licenseCC BY-NC-ND 4.0 DEED Atribución-NoComercial-SinDerivadas 4.0 Internacional
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subjectFluorescence probing
dc.subjectHyperbranched polyglycidol
dc.subjectMultimolecular aggregates
dc.subjectp-Alkylphenols
dc.subjectPartition coefficients
dc.titleSolubilization of phenols by multimolecular aggregates formed by low molecular weight hyperbranched polyglycidol
dc.typeArtículo
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