Locus of Adhesion and Autoaggregation (LAA), a pathogenicity island present in emerging Shiga Toxin-producing Escherichia coli strains

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dc.contributor.authorMontero, David A.
dc.contributor.authorVelasco, Juliana
dc.contributor.authorDel Canto, Felipe
dc.contributor.authorPuente, Jose L.
dc.contributor.authorPadola, Nora L.
dc.contributor.authorRasko, David A.
dc.contributor.authorFarfán, Mauricio
dc.contributor.authorSalazar, Juan C.
dc.contributor.authorVidal, Roberto
dc.date.accessioned2023-10-23T16:06:48Z
dc.date.available2023-10-23T16:06:48Z
dc.date.issued2017-12
dc.descriptionIndexación: Scopuses
dc.description.abstractShiga Toxin-producing Escherichia coli (STEC) are a group of foodborne pathogens associated with diarrhea, dysentery, hemorrhagic colitis (HC) and hemolytic uremic syndrome (HUS). Shiga toxins are the major virulence factor of these pathogens, however adhesion and colonization to the human intestine is required for STEC pathogenesis. A subset of STEC strains carry the Locus of Enterocyte Effacement (LEE) pathogenicity island (PAI), which encodes genes that mediate the colonization of the human intestine. While LEE-positive STEC strains have traditionally been associated with human disease, the burden of disease caused by STEC strains that lacks LEE (LEE-negative) has increased recently in several countries; however, in the absence of LEE, the molecular pathogenic mechanisms by STEC strains are unknown. Here we report a 86-kb mosaic PAI composed of four modules that encode 80 genes, including novel and known virulence factors associated with adherence and autoaggregation. Therefore, we named this PAI as Locus of Adhesion and Autoaggregation (LAA). Phylogenomic analysis using whole-genome sequences of STEC strains available in the NCBI database indicates that LAA PAI is exclusively present in a subset of emerging LEE-negative STEC strains, including strains isolated from HC and HUS cases. We suggest that the acquisition of this PAI is a recent evolutionary event, which may contribute to the emergence of these STEC. © 2017 The Author(s).es
dc.description.urihttps://www-nature-com.recursosbiblioteca.unab.cl/articles/s41598-017-06999-y
dc.identifier.citationScientific Reports Volume 7, Issue 11 December 2017 Article number 7011es
dc.identifier.doi10.1038/s41598-017-06999-y
dc.identifier.issn2045-2322
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/53558
dc.language.isoenes
dc.publisherNature Publishing Groupes
dc.rights.licenseCC BY 4.0 DEED
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.titleLocus of Adhesion and Autoaggregation (LAA), a pathogenicity island present in emerging Shiga Toxin-producing Escherichia coli strainses
dc.typeArtículoes
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