Hantavirus Gc glycoprotein: Evidence for a class ll fusion protein

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dc.contributor.authorTischler, Nicole D.
dc.contributor.authorGonzales, Angel
dc.contributor.authorPerez-Acle, Tomas
dc.contributor.authorRosemblatt, Mario
dc.contributor.authorValenzuela, Pablo D.T.
dc.date.accessioned2023-10-15T17:06:07Z
dc.date.available2023-10-15T17:06:07Z
dc.date.issued2005-11
dc.descriptionINDEXACIÓN: SCOPUS.es
dc.description.abstractHantavirus cell entry is promoted by its envelope glycoproteins, Gn and Gc, through cell attachment and by fusion between viral and endosomal membranes at low pH. However, the role of Gn and Gc in receptor binding and cell fusion has not yet been defined. In this work, a sequence presenting characteristics similar to those of class II fusion peptides (FPs) of alphavirus E1 and flavivirus E proteins is identified within the hantavirus Gc glycoprotein. A three-dimensional comparative molecular model based on crystallographic data of tick-borne encephalitis virus E protein is proposed for the Andes virus (ANDV) Gc ectodomain, which supports a feasible class II fusion-protein fold. In vitro experimental evidence is provided for the binding activity of the ANDV FP candidate to artificial membranes, as demonstrated by fluorescence anisotropy assays. Taken together, these results support the hypothesis that the Gc glycoprotein of hantaviruses and of other members of the family Bunyaviridae directs the viral fusion activity and that it may be classified as a class II viral fusion protein. © 2005 SGM.es
dc.identifier.citationJournal of General Virology, Volume 86, Issue 11, Pages 2937 - 2947, November 2005es
dc.identifier.issn00221317
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/53467
dc.language.isoenes
dc.publisherMicrobiology Societyes
dc.subjectAmino Acid Sequencees
dc.subjectHantaviruses
dc.subjectModels, Moleculares
dc.subjectMolecular Sequence Dataes
dc.subjectProtein Bindinges
dc.subjectViral Envelope Proteinses
dc.subjectViral Fusion Proteinses
dc.titleHantavirus Gc glycoprotein: Evidence for a class ll fusion proteines
dc.typeArtículoes
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