Voluntary Running Triggers VGF-Mediated Oligodendrogenesis to Prolong the Lifespan of Snf2h-Null Ataxic Mice

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dc.contributor.authorAlvarez-Saavedra, M
dc.contributor.authorDe Repentigny, Y
dc.contributor.authorYang, D
dc.contributor.authorO'Meara, RW
dc.contributor.authorYan, KQ
dc.contributor.authorHashem, LE
dc.contributor.authorRacacho, L
dc.contributor.authorIoshikhes, I
dc.contributor.authorBulman, DE
dc.contributor.authorParks, RJ
dc.contributor.authorKothary, R
dc.contributor.authorPicketts, DJ
dc.date.accessioned2017-02-09T19:21:34Z
dc.date.available2017-02-09T19:21:34Z
dc.date.issued2016-10
dc.descriptionIndexación: Web of Sciencees
dc.description.abstractExercise has been argued to enhance cognitive function and slow progressive neurodegenerative disease. Although exercise promotes neurogenesis, oligodendrogenesis and adaptive myelination are also significant contributors to brain repair and brain health. Nonetheless, the molecular details underlying these effects remain poorly understood. Conditional ablation of the Snf2h gene impairs cerebellar development producing mice with poor motor function, progressive ataxia, and death between postnatal days 25-45. Here, we show that voluntary running induced an endogenous brain repair mechanism that resulted in a striking increase in hindbrain myelination and the long-term survival of Snf2h cKO mice. Further experiments identified the VGF growth factor as a major driver underlying this effect. VGF neuropeptides promote oligodendrogenesis in vitro, whereas Snf2h cKO mice treated with full-length VGF-encoding adenoviruses removed the requirement of exercise for survival. Together, these results suggest that VGF delivery could represent a therapeutic strategy for cerebellar ataxia and other pathologies of the CNS.es
dc.description.urihttp://www.sciencedirect.com/science/article/pii/S2211124716312529
dc.identifier.citationCELL REPORTS, 17 (3):862-875es
dc.identifier.issn2211-1247
dc.identifier.otherhttp://dx.doi.org/10.1016/j.celrep.2016.09.030
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/2983
dc.language.isoenes
dc.publisherCELL PRESSes
dc.subjectHIPPOCAMPAL NEUROGENESISes
dc.subjectADENOVIRUS VECTORSes
dc.subjectNEUROPEPTIDE VGFes
dc.subjectPROGENITOR CELLSes
dc.subjectPRECURSOR CELLSes
dc.subjectSPATIAL MEMORYes
dc.subjectDENTATE GYRUSes
dc.subjectEARLY PHASEes
dc.subjectGENE VGFes
dc.subjectEXERCISEes
dc.titleVoluntary Running Triggers VGF-Mediated Oligodendrogenesis to Prolong the Lifespan of Snf2h-Null Ataxic Micees
dc.typeArtículoes
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