Synthesis and antiproliferative activity of new cyclodiprenyl phenols against select cancer cell lines

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dc.contributor.authorSaid, B.
dc.contributor.authorMontenegro, I.
dc.contributor.authorValenzuela, M.
dc.contributor.authorOlguín, Y.
dc.contributor.authorCaro, N.
dc.contributor.authorWerner, E.
dc.contributor.authorGodoy, P.
dc.contributor.authorVillena, J.
dc.contributor.authorMadrid, A.
dc.date.accessioned2019-12-06T15:20:06Z
dc.date.available2019-12-06T15:20:06Z
dc.date.issued2018-09
dc.descriptionIndexación: Scopus.es
dc.description.abstractSix new cyclodiprenyl phenols were synthesized by direct coupling of perillyl alcohol and the appropriate phenol. Their structures were established by IR, HRMS and mainly NMR. Three human cancer cell lines-breast (MCF-7), prostate (PC-3) and colon (HT-29)-were used in antiproliferative assays, with daunorubicin and dunnione as positive controls. Results described in the article suggest that dihydroxylated compounds 2-4 and monohydroxylated compound 5 display selectivity against cancer cell lines, cytotoxicity, apoptosis induction, and mitochondrial membrane impairment capacity. Compound 2 was identified as the most effective of the series by displaying against all cancer cell lines a cytotoxicity close to dunnione antineoplastic agent, suggesting that the cyclodiprenyl phenols from perillyl alcohol deserve more extensive investigation of their potential medicinal applications. © 2018 by the authors.es
dc.description.urihttps://www.mdpi.com/1420-3049/23/9/2323
dc.identifier.citationMolecules, 23(9), art. no. 2323.es
dc.identifier.issn1420-3049
dc.identifier.otherDOI: 10.3390/molecules23092323
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/11249
dc.language.isoenes
dc.publisherMDPI AGes
dc.subjectAntiproliferative agentses
dc.subjectCyclodiprenyl phenolses
dc.subjectPerillyl alcoholes
dc.subjectSynthesises
dc.titleSynthesis and antiproliferative activity of new cyclodiprenyl phenols against select cancer cell lineses
dc.typeArtículoes
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