A novel endosomal sorting complex required for transport (ESCRT) component in arabidopsis thaliana controls cell expansion and development

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dc.contributor.authorReyes, Francisca C.
dc.contributor.authorBuono, Rafael A.
dc.contributor.authorRoschzttardtz, Hannetz
dc.contributor.authorDi Rubbo, Simone
dc.contributor.authorYeun, Li Huey
dc.contributor.authorRussinova, Eugenia
dc.contributor.authorOtegui, Marisa S.
dc.date.accessioned2023-06-27T14:36:38Z
dc.date.available2023-06-27T14:36:38Z
dc.date.issued2014-02
dc.descriptionIndexación: Scopus.es
dc.description.abstractESCRT proteins mediate membrane remodeling and scission events and are essential for endosomal sorting of plasma membrane proteins for degradation. We have identified a novel, plant-specific ESCRT component called PROS (POSITIVE REGULATOR OF SKD1) in Arabidopsis thaliana. PROS has a strong positive effect on the in vitro ATPase activity of SKD1 (also known as Vacuolar Protein Sorting 4 or VPS4), a critical component required for ESCRT-III disassembly and endosomal vesiculation. PROS interacts with both SKD1 and the SKD1-positive regulator LIP5/VTA1. We have identified a putative MIM domain within PROS that mediate the interaction with the MIT domain of SKD1. Interestingly, whereas MIM domains are commonly found at the C terminus of ESCRT-III subunits, the PROS MIM domain is internal. The heterologous expression of PROS in yeast mutant cells lacking Vta1p partially rescues endosomal sorting defects. PROS is expressed in most tissues and cells types in Arabidopsis thaliana. Silencing of PROS leads to reduced cell expansion and abnormal organ growth.es
dc.description.urihttps://www-sciencedirect-com.recursosbiblioteca.unab.cl/science/article/pii/S0021925820441389?via%3Dihub
dc.identifier.citationJournal of Biological Chemistry. Volume 289, Issue 8, Pages 4980 - 4988. 21 February 2014es
dc.identifier.doi10.1074/jbc.M113.529685
dc.identifier.issn0021-9258
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/51079
dc.language.isoenes
dc.publisherAmerican Society for Biochemistry and Molecular Biology Inc.es
dc.rights.licenseAtribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectCell Biologyes
dc.subjectCell Growthes
dc.subjectEndosomeses
dc.subjectEnzyme Purificationes
dc.subjectGene Silencinges
dc.subjectMembrane Traffickinges
dc.subjectPlantes
dc.subjectProtein Purificationes
dc.titleA novel endosomal sorting complex required for transport (ESCRT) component in arabidopsis thaliana controls cell expansion and developmentes
dc.typeArtículoes
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