Role of Wnt Signaling in Adult Hippocampal Neurogenesis in Health and Disease

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dc.contributor.authorArredondo, Sebastian B.
dc.contributor.authorValenzuela-Bezanilla, Daniela
dc.contributor.authorMardones, Muriel D.
dc.contributor.authorVarela-Nallar, Lorena
dc.date.accessioned2022-06-03T15:10:32Z
dc.date.available2022-06-03T15:10:32Z
dc.date.issued2020-09
dc.descriptionIndexación: Scopus.es
dc.description.abstractNeurogenesis persists during adulthood in the dentate gyrus of the hippocampus. Signals provided by the local hippocampal microenvironment support neural stem cell proliferation, differentiation, and maturation of newborn neurons into functional dentate granule cells, that integrate into the neural circuit and contribute to hippocampal function. Increasing evidence indicates that Wnt signaling regulates multiple aspects of adult hippocampal neurogenesis. Wnt ligands bind to Frizzled receptors and co-receptors to activate the canonical Wnt/β-catenin signaling pathway, or the non-canonical β-catenin-independent signaling cascades Wnt/Ca2+ and Wnt/planar cell polarity. Here, we summarize current knowledge on the roles of Wnt signaling components including ligands, receptors/co-receptors and soluble modulators in adult hippocampal neurogenesis. Also, we review the data suggesting distinctive roles for canonical and non-canonical Wnt signaling cascades in regulating different stages of neurogenesis. Finally, we discuss the evidence linking the dysfunction of Wnt signaling to the decline of neurogenesis observed in aging and Alzheimer’s disease. © Copyright © 2020 Arredondo, Valenzuela-Bezanilla, Mardones and Varela-Nallar.es
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fcell.2020.00860/full
dc.identifier.citationFrontiers in Cell and Developmental BiologyOpen AccessVolume 816 September 2020 Article number 860es
dc.identifier.doi10.3389/fcell.2020.00860
dc.identifier.issn2296634X
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/22708
dc.language.isoenes
dc.publisherFrontiers Media S.Aes
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectadult neurogenesises
dc.subjectaginges
dc.subjectAlzheimer’s diseasees
dc.subjecthippocampuses
dc.subjectWntes
dc.titleRole of Wnt Signaling in Adult Hippocampal Neurogenesis in Health and Diseasees
dc.typeArtículoes
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