Examinando por Autor "González, Carlos"

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    A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection
    (BioMed Central Ltd, 2020-08) Cruces, Pablo; Retamal, Jaime; Hurtado, Daniel E.; Erranz, Benjamín; Iturrieta, Pablo; González, Carlos; Díaz, Franco
    Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing. In addition, we discuss the current approach to respiratory support for COVID-19 under this point of view. © 2020 The Author(s).
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    Estudio inmunomorfométrico comparativo de la actividad angiogénica y poliferativa en mastocitoma canino de bajo y alto grado de malignidad, antes y después del tratamiento con Masinitib
    (Universidad Andrés Bello (Chile), 2014) Mejías Ruiz, Pamela; González, Carlos; Facultad de Medicina
    De las neoplasias caninas, una de las más comunes es el mastocitoma, constituyendo entre un 7-21% de los tumores cutáneos caninos y un 6% de los tumores en general. Se originan principalmente en la dermis o tejido subcutáneo y sus causas aún son desconocidas, sin embargo es comúnmente asociada a inflamaciones crónicas y sustancias irritantes. Actualmente, el tratamiento para estos pacientes es mediante remoción quirúrgica con márgenes estandarizados, acompañado de quimioterapia. Sin embargo, los resultados no son los esperados, pues no existe remisión completa de la neoplasia. Por esto es necesario considerar el uso de terapia dirigida, que permita controlar a las células neoplásicas remanentes. Evidencias recientes indican de que existen mutaciones en el proto-oncogén c-kit presente en los mastocitos y que esto conllevaría a la angiogénesis y desorden proliferativo celular en los mastocitomas. Por lo que en este estudio se investigó el efecto del bloqueo del receptor kit mediante tratamiento con Masitinib, comparando resultados previos y posteriores a la terapia con técnica Tissue Micro Array, histoquímica e inmunohistoquímica. Los resultados obtenidos fueron los esperados según la hipótesis planteada y también son concordantes con estudios recientes realizados por otros investigadores, demostrando que Masitinib puede ser eficaz como terapia contra mastocitoma canino ya que induce una reducción sustancial en la proliferación celular y angiogénesis, junto a un aumento índice de apoptosis posterior al tratamiento de 7 días.
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    Ítem
    Sporotrichosis Outbreak Due to Sporothrix brasiliensis in Domestic Cats in Magallanes, Chile: A One-Health-Approach Study
    (MDPI, 2023-02) Thomson, Pamela; González, Carlos; Blank, Olivia; Ramírez, Valentina; Río, Camila del; Santibáñez, Sebastián; Pena, Pamela
    Sporotrichosis is an implantation mycosis with subcutaneo-lymphatic or, more rarely, a viscerally disseminated affection; it can be acquired through traumatic percutaneous inoculation of the fungus present in soil or plant matter, or by feline scratching. Among the causative agents, Sporothrix brasiliensis is considered the most virulent species with a high prevalence in Brazil and recently in Argentina. Objective: To describe a S. brasiliensis outbreak in domestic and feral cats detected in the Magallanes region of southern Chile. Materials and Methods: Between the months of July and September 2022, three cats presented with suppurative subcutaneous lesions located mainly on the head and thoracic limbs. The cytology revealed the presence of yeasts with morphological characteristics suggestive of Sporothrix spp. The histopathology confirmed pyogranulomatous subcutaneous lesions associated with the presence of the same yeasts. The fungal culture followed by the partial gene sequence and analysis of the ITS region confirmed the diagnosis of the S. brasiliensis as the causative agent. The cats were treated with itraconazole associated in one case with potassium iodide. The evolution of the patients was favorable in all cases. Conclusions: An outbreak caused by S. brasiliensis was detected in domestic and feral cats in austral Chile. The correct identification of this fungus and antifungigram is essential for treatment decisions and for designing dissemination control and prevention programs under a one health approach that consider the health of people, animals, and the environment. © 2023 by the authors.
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    The influence of the socio-cultural context in second languague learning : some phonetic traits.
    (Universidad Andrés Bello, 2007) Comte, Jorge; González, Carlos; Ortega, Leslie; Magaña, Héctor; Facultad de Educación y Ciencias Sociales
    The effect of the socio cultural context of students on their education is an issue on which there is general disagreement. This situation is particularly true when it comes to the importance of the social background in second language leaming. This non-experimental, descriptive study analyzes the role that the background of students from deprived soci~ultural contexts plays in the acquisition of their first language (Spanish), and the leaming of a second language (English). This research explores certain phonetic traits that are influenced by the students' background and social dialect.