Examinando por Autor "Vilos, Cristiana, c"
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Ítem A solvent-free thermosponge nanoparticle platform for efficient delivery of labile proteins(Nano Letters, 2014-11) Choi, Won Ila; Kamaly, Nazilaa; Riol-Blanco, Lorenab; Lee, In-Hyuna; Wu, Juna; Swami, Archanaa; Vilos, Cristiana, c; Yameen, Basita; Yu, Mikyunga; Shi, Jinjuna; Tabas, Irad, e, f; Von Andrian, Ulrich H.; Jon, Sangyongg; Farokhzad, Omid C.Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a solvent-free polymer thermo-expansion mechanism with clinical potential, capable of effectively delivering a range of therapeutic proteins in a sustained manner with no loss of bioactivity, with improved biological half-lives and efficacy in vivo. © 2014 American Chemical Society.