Rosmarinic acid prevents fibrillization and diminishes vibrational modes associated to β sheet in tau protein linked to Alzheimer’s disease

Vista sencilla de ítem
dc.contributor.authorCornejo, Alberto
dc.contributor.authorAguilar Sandoval, Felipe
dc.contributor.authorCaballero, Leonardo
dc.contributor.authorMachuca, Luis
dc.contributor.authorMuñoz, Patricio
dc.contributor.authorCaballero, Julio
dc.contributor.authorPerry, George
dc.contributor.authorArdiles, Alejandro
dc.contributor.authorAreche, Carlos
dc.contributor.authorMelo, Francisco
dc.date.accessioned2022-07-08T20:29:39Z
dc.date.available2022-07-08T20:29:39Z
dc.date.issued2017-01
dc.descriptionIndexación: Scopuses
dc.description.abstractAlzheimer’s disease is a common tauopathy where fibril formation and aggregates are the hallmark of the disease. Efforts targeting amyloid-β plaques have succeeded to remove plaques but failed in clinical trials to improve cognition; thus, the current therapeutic strategy is at preventing tau aggregation. Here, we demonstrated that four phenolic diterpenoids and rosmarinic acid inhibit fibrillization. Since, rosmarinic acid was the most active compound, we observe morphological changes in atomic force microscopy images after treatment. Hence, rosmarinic acid leads to a decrease in amide regions I and III, indicating that rosmarinic acid prevents β-sheet assembly. Molecular docking study inside the steric zipper model of the hexapeptide 306VQIVYK311 involved in fibrillization and β sheet formation, suggests that rosmarinic acid binds to the steric zipper with similar chemical interactions with respect to those observed for orange G, a known pharmacofore for amyloid. © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.es
dc.identifier.citationJournal of Enzyme Inhibition and Medicinal Chemistry Volume 32, Issue 1, Pages 945 - 9531 January 2017es
dc.identifier.doi10.1080/14756366.2017.1347783
dc.identifier.issn1475-6366
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/23220
dc.language.isoenes
dc.publisherJournal of Enzyme Inhibition and Medicinal Chemistryes
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectaggregationes
dc.subjectAlzheimer’s diseasees
dc.subjectinhibitiones
dc.subjectpharmacophorees
dc.subjecttaues
dc.subjectβ-sheetes
dc.titleRosmarinic acid prevents fibrillization and diminishes vibrational modes associated to β sheet in tau protein linked to Alzheimer’s diseasees
dc.typeArtículoes
Archivos
Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
Cornejo, Alberto - Rosmarinic-acid-prevents-fibrillization-and-diminishes-vibrational-modes-associated-to--sheet-in-tau-protein-linked-to-Alzheimers-diseaseJournal-of-Enzyme-Inhibition-and-Medicinal-Chemistry.pdf
Tamaño:
1.75 MB
Formato:
Adobe Portable Document Format
Descripción:
Texto completo en ingles
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
FM - Artículos de Revista