Mutantelec: An In Silico mutation simulation platform for comparative electrostatic potential profiling of proteins
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Archivos
Fecha
2017-03
Profesor/a Guía
Facultad/escuela
Idioma
en
Título de la revista
ISSN de la revista
Título del volumen
Editor
NLM (Medline)
Nombre de Curso
Licencia CC
ATRIBUCIÓN 4.0 INTERNACIONAL
CC BY 4.0
Deed
Licencia CC
https://creativecommons.org/licenses/by/4.0/deed.es
Resumen
The electrostatic potential plays a key role in many biological processes like determining the affinity of a ligand to a given protein target, and they are responsible for the catalytic activity of many enzymes. Understanding the effect that amino acid mutations will have on the electrostatic potential of a protein, will allow a thorough understanding of which residues are the most important in a protein. MutantElec, is a friendly web application for in silico generation of site-directed mutagenesis of proteins and the comparison of electrostatic potential between the wild type protein and the mutant(s), based on the three-dimensional structure of the protein. The effect of the mutation is evaluated using different approach to the traditional surface map. MutantElec provides a graphical display of the results that allows the visualization of changes occurring at close distance from the mutation and thus uncovers the local and global impact of a specific change. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.
Notas
Indexación: Scopus
Palabras clave
bioinformatics, Electrostatic potential, p53, PDB, protein engineering, rational protein design, site-directed mutagenesis
Citación
Journal of computational chemistry Volume 38, Issue 7, Pages 467 - 47415 March 2017
DOI
10.1002/jcc.24712