Mutantelec: An In Silico mutation simulation platform for comparative electrostatic potential profiling of proteins

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dc.contributor.authorValdebenito-Maturana, Braulio
dc.contributor.authorReyes-Suarez, Jose Antonio
dc.contributor.authorHenriquez, Jaime
dc.contributor.authorHolmes, David S.
dc.contributor.authorQuatrini, Raquel
dc.contributor.authorPohl, Ehmke
dc.contributor.authorArenas-Salinas, Mauricio
dc.date.accessioned2024-06-26T16:23:47Z
dc.date.available2024-06-26T16:23:47Z
dc.date.issued2017-03
dc.descriptionIndexación: Scopus
dc.description.abstractThe electrostatic potential plays a key role in many biological processes like determining the affinity of a ligand to a given protein target, and they are responsible for the catalytic activity of many enzymes. Understanding the effect that amino acid mutations will have on the electrostatic potential of a protein, will allow a thorough understanding of which residues are the most important in a protein. MutantElec, is a friendly web application for in silico generation of site-directed mutagenesis of proteins and the comparison of electrostatic potential between the wild type protein and the mutant(s), based on the three-dimensional structure of the protein. The effect of the mutation is evaluated using different approach to the traditional surface map. MutantElec provides a graphical display of the results that allows the visualization of changes occurring at close distance from the mutation and thus uncovers the local and global impact of a specific change. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.
dc.description.urihttps://onlinelibrary-wiley-com.recursosbiblioteca.unab.cl/doi/10.1002/jcc.24712
dc.identifier.citationJournal of computational chemistry Volume 38, Issue 7, Pages 467 - 47415 March 2017
dc.identifier.doi10.1002/jcc.24712
dc.identifier.issn1096-987X
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/57991
dc.language.isoen
dc.publisherNLM (Medline)
dc.rights.licenseATRIBUCIÓN 4.0 INTERNACIONAL CC BY 4.0 Deed
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectbioinformatics
dc.subjectElectrostatic potential
dc.subjectp53
dc.subjectPDB
dc.subjectprotein engineering
dc.subjectrational protein design
dc.subjectsite-directed mutagenesis
dc.titleMutantelec: An In Silico mutation simulation platform for comparative electrostatic potential profiling of proteins
dc.typeArtículo
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