Microwave-Assisted Semisynthesis and Leishmanicidal Activity of Some Phenolic Constituents from Lichens

Vista sencilla de ítem
dc.contributor.authorCastañeta, Grover
dc.contributor.authorVillagomez, Rodrigo
dc.contributor.authorSalamanca, Efrain
dc.contributor.authorCanaviri-Paz, Pamela
dc.contributor.authorBravo, José A.
dc.contributor.authorVila, José L.
dc.contributor.authorBárcenas-Pérez, Daniela
dc.contributor.authorCheel, José
dc.contributor.authorSepúlveda, Beatriz
dc.contributor.authorGiménez, Alberto
dc.contributor.authorAreche, Carlos
dc.date.accessioned2023-12-06T16:02:33Z
dc.date.available2023-12-06T16:02:33Z
dc.date.issued2023-10
dc.descriptionINDEXACIÓN: SCOPUS.es
dc.description.abstractLeishmaniasis is considered one of the most untreated tropical diseases in the world. In this study, we investigated the in vitro leishmanicidal activity and cytotoxicity of various isolated lichen substances, including atranorin (1), usnic acid (2), gyrophoric acid (3), salazinic acid (4), galbinic acid (5), and parietin (6), and some semi-synthetic imine derivatives of usnic acid (7, 8, 9) and atranorin (10, 11, 12, 13). Imine condensation reactions with hydrazine and several amines were assisted by microwave heating, an efficient and eco-friendly energy source. The most interesting result was obtained for compound 2, which has high leishmanicidal activity but also high cytotoxicity. This cytotoxicity was mitigated in its derivative, 9, with better selectivity and high antileishmanic activity. This result may indicate that the usnic acid derivative (9) obtained using condensation with two cyclohexylamine groups is a promising lead compound for the discovery of new semisynthetic antiparasitic drugs. © 2023 by the authors.es
dc.identifier.citationSeparations, Volume 10, Issue 10, October 2023, Article number 524es
dc.identifier.doi10.3390/separations10100524
dc.identifier.issn22978739
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/54452
dc.language.isoenes
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)es
dc.rights.licenseCC BY 4.0 DEED Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectatranorin derivativeses
dc.subjectcytotoxicityes
dc.subjectgreen chemistryes
dc.subjectiminees
dc.subjectleishmaniaes
dc.subjectpyrazolinees
dc.subjectusnic acid derivativeses
dc.titleMicrowave-Assisted Semisynthesis and Leishmanicidal Activity of Some Phenolic Constituents from Lichenses
dc.typeArtículoes
Archivos
Bloque original
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
separations-10-00524.pdf
Tamaño:
1.6 MB
Formato:
Adobe Portable Document Format
Descripción:
TEXTO COMPLETO EN INGLÉS
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
FCE - Artículos de Revista