Anogenital lesions produced by Human Papillomavirus. Prevalence study in children and adolescent not vaccinated

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dc.contributor.authorPatricia Romero, Fuentes
dc.contributor.authorEugenio Ramírez V.
dc.contributor.authorMónica Muñoz O.
dc.contributor.authorPaula Muñoz M.
dc.contributor.authorCarolina González L.
dc.contributor.authorCarolina Orellana C.
dc.contributor.authorCarolina Pastene S.
dc.contributor.authorMontserrat Balanda A.
dc.contributor.authorNicolásvergara V.
dc.contributor.authorAlvaro Reyes P.
dc.date.accessioned2025-03-14T15:06:46Z
dc.date.available2025-03-14T15:06:46Z
dc.date.issued2023
dc.descriptionIndexación: Scopus
dc.description.abstractIn Chilean children and adolescents, human papillomavirus (HPV) infection prevalence is unknown. In 2014, the HPV vaccine was incorporated into the National Immunization Program for girls, and since 2019 for boys. Objective: To determine the prevalence, genotypes, and characteristics of HPV infection in children and adolescents with anogenital lesions not vaccinated against HPV. Patients and Method: Children and adolescents with anogenital lesions who consulted at the Luis Calvo Mac-kenna Children’s Hospital between 2013 and 2017 were studied. The reason for consultation, age, sex, family history of HPV lesions, history of sexual abuse, and consensual sexual activity were recorded. HPV was detected by PCR and typification by reverse hybridization of the L1 gene. The samples were analyzed in the Oncogenic Virus Section of the Institute of Public Health. Results: 110 patients were studied; 44.5% were children. HPV was detected in 34 cases (30.9% [CI95% 22.4-40.4]), 22 (44.9%) were children and 12 (19.7%) adolescents. Eleven (91.7%) adolescents had a history of sexual contact (p < 0.005); 4 (18.2%) children disclosed sexual abuse. HPV was found in 25% of patients with genital lesions and 50% with perianal lesions (p < 0.015). The most frequent genotypes were 59, 58, 16, 18, 6, and 11. Only low-risk genotypes were detected in children and high-risk genotypes were detected in 11/12 (91.7%) of HPV (+) adolescents. Conclusion: The prevalence of HPV infection was 30%. In adolescents, the infection was related to sexual contact and high-risk HPV. In children, it was associated with low-risk genotypes. Perianal lesions are more frequently associated with HPV infection than genital lesions in children and adolescents. The visual inspection does not allow to specify the etiology of the genital lesions, so it is necessary to perform a PCR test for HPV. © 2023, Sociedad Chilena de Pediatria. All rights reserved
dc.description.urihttps://www.revistachilenadepediatria.cl/index.php/rchped/article/view/3534
dc.identifier.doi10.32641/andespediatr.v94i1.3534
dc.identifier.issn24526053
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/63774
dc.language.isoes
dc.publisherAndes PediatricaOpen AccessVolume 94, Issue 1, Pages 29 - 36January-February 2023
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International CC BY-NC-ND 4.0 Deed
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectadolescent
dc.subjectchild
dc.subjectconsultation
dc.subjectcontrolled study
dc.subjectfamily history
dc.subjectfemale
dc.subjectgene frequency
dc.subjectgenetic susceptibility
dc.subjectgenotype
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectnonhuman
dc.subjectpolymerase chain reaction
dc.subjectprevalence
dc.subjectpublic health
dc.subjectsexual abuse
dc.subjectsexual behavior
dc.subjecttumor virus
dc.subjectWart virus
dc.subjectcross-sectional study
dc.subjectgenetics
dc.subjectPapillomaviridae
dc.subjectpapillomavirus infection
dc.subjectWart virus
dc.titleAnogenital lesions produced by Human Papillomavirus. Prevalence study in children and adolescent not vaccinated
dc.title.alternativeLesiones anogenitales por Virus Papiloma Humano. Estudio de prevalencia en niños, niñas y adolescentes no vacunados
dc.typeArtículo
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