Characterization of MgtC, a virulence factor of Salmonella enterica serovar typhi

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dc.contributor.authorRetamal, Patricio
dc.contributor.authorCastillo-Ruiz, Mario
dc.contributor.authorMora, Guido C.
dc.date.accessioned2024-04-09T14:45:29Z
dc.date.available2024-04-09T14:45:29Z
dc.date.issued2009-04-14
dc.descriptionINDEXACIÓN: SCOPUS.
dc.description.abstractThe MgtC is a virulence factor in Salmonella Typhimurium that is required for growth at low-Mg2+ concentrations and intramacrophage survival. This gene is codified in a conserved region of the Salmonella pathogenicity island 3 (SPI-3), and is also present in the chromosome of other Salmonella serovars. In this study we characterized the MgtC factor in S. Typhi, a human specific pathogen, by using mgtC and SPI-3 mutant strains. We found that MgtC is the most important factor codified in the SPI-3 of S. Typhi for growth in low-Mg2+ media and survival within human cells. In addition, by using reporter genes we determined that the low-Mg2+ concentration, acidic media and PhoP regulator induce mgtC expression in S. Typhi. We suggest that MgtC is the most important virulence factor codified in the SPI-3 of S. Typhi. © 2009 Retamal et al.
dc.identifier.citationPLoS ONE, Volume 4, Issue 5, 14 May 2009, Article number e5551
dc.identifier.doi10.1371/journal.pone.0005551
dc.identifier.issn1932-6203
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/55785
dc.language.isoen
dc.publisherPublic Library of Science
dc.rights.licenseCC BY 4.0 DEED Atribución 4.0 Internacional
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectBacterial Proteins
dc.subjectCation Transport Proteins
dc.subjectConserved Sequence
dc.subjectGenes, Bacterial
dc.subjectGenes, Reporter
dc.subjectMagnesium
dc.subjectPhenotype
dc.subjectSalmonella typhi
dc.subjectVirulence Factors
dc.titleCharacterization of MgtC, a virulence factor of Salmonella enterica serovar typhi
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