Forward genetic screens in zebrafish identify pre-mRNA-processing pathways regulating early T cell development

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dc.contributor.authorIwanami, Norimasa
dc.contributor.authorSikora, Katarzyna
dc.contributor.authorRichter, Andreas S.
dc.contributor.authorMönnich, Maren
dc.contributor.authorGuerri, Lucia
dc.contributor.authorSoza-Ried, Cristian
dc.contributor.authorLawir, Divine-Fondzenyuy
dc.contributor.authorMateos, Fernando
dc.contributor.authorHess, Isabell
dc.contributor.authorO'Meara, Connor P.
dc.contributor.authorSchorpp, Michael
dc.contributor.authorBoehm, Thomas
dc.date.accessioned2023-05-12T17:30:48Z
dc.date.available2023-05-12T17:30:48Z
dc.date.issued2016-11
dc.descriptionIndexación: Scopus.es
dc.description.abstractymphocytes represent basic components of verte brate adaptive immune systems, suggesting the util ity of non-mammalian models to define the molecular basis of their development and differentiation. Our forward genetic screens in zebrafish for recessive mutations affecting early T cell development re vealed several major genetic pathways. The iden tification of lineage-specific transcription factors and specific components of cytokine signaling and DNA replication and/or repair pathways known from studies of immunocompromised mammals pro vided an evolutionary cross-validation of the screen design. Unexpectedly, however, genes encoding proteins required for pre-mRNA processing were en riched in the collection of mutants identified here. In both zebrafish and mice, deficiency of the splice regulator TNPO3 impairs intrathymic T cell differenti ation, illustrating the evolutionarily conserved and cell-type-specific functions of certain pre-mRNA processing factors for T cell development.es
dc.description.urihttps://www.sciencedirect.com/science/article/pii/S2211124716315236
dc.identifier.citationCell Reports. Volume 17, Issue 9, Pages 2259 - 2270. 22 November 2016es
dc.identifier.doiDOI: 10.1016/j.celrep.2016.11.003
dc.identifier.issn2211-1247
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/49575
dc.language.isoenes
dc.publisherElsevier B.V.es
dc.rights.licenseAtribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectT Cell Developmentes
dc.subjectGenetic Screenes
dc.subjectImmunodeficiencyes
dc.subjectZebrafishes
dc.subjectMousees
dc.subjectPre-mRNAes
dc.subjectSplicinges
dc.titleForward genetic screens in zebrafish identify pre-mRNA-processing pathways regulating early T cell developmentes
dc.typeArtículoes
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