Impact of 1% malic acid spray on the oral health-related quality of life of patients with xerostomia

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dc.contributor.authorNiklander, S.
dc.contributor.authorFuentes, F.
dc.contributor.authorSanchez, D.
dc.contributor.authorAraya, V.
dc.contributor.authorChiappini, G.
dc.contributor.authorMartinez, R.
dc.contributor.authorMarshall, M.
dc.date.accessioned2019-06-19T19:39:10Z
dc.date.available2019-06-19T19:39:10Z
dc.date.issued2018-06
dc.descriptionIndexación: Scopus.es_ES
dc.description.abstractDry mouth sensation, also known as xerostomia, is a common clinical problem with an increasing prevalence. Although recent studies have reported promissory results of malic acid, none have evaluated the impact of malic acid on the oral health-related quality of life (OHRQoL) of patients with xerostomia. Thus, this study aimed to evaluate the impact of 1% malic acid, combined with fluoride and xylitol, on the OHRQoL of patients with xerostomia. We enrolled 70 patients and randomly allocated them into two groups: the intervention group (applied topical sialogogue with 1% malic acid) and the control group (applied a placebo). We assessed the OHRQoL and severity of xerostomia before and after treatment with the Spanish version of the Oral Health Impact Profile-14 questionnaire (OHIP-14sp) and a visual analogue scale (VAS), respectively. In addition, stimulated and non-stimulated salivary flow rates before and after treatments were also measured. In total, 60 patients completed the study. According to the VAS, both sprays significantly improved dry mouth sensation (P < 0.001). However, OHIP-14sp total scores decreased significantly in the intervention group from 20.8 ± 10.4 to 16.5 ± 9.5 (P < 0.001), indicating an improvement in the OHRQoL. No significant differ- ences were observed in the control group (P > 0.05). Furthermore, non-stimulated salivary flow rates significantly increased in the intervention group from 0.25 ± 0.22 to 0.33 ± 0.33 mL/min (P < 0.001). Overall, this study demonstrated that malic acid improves the OHRQoL and dry mouth sensation in patients with xerostomia. © 2018, Nihon University, School of Dentistry. All rights reserved.es_ES
dc.description.urihttps://www.jstage.jst.go.jp/article/josnusd/60/2/60_17-0164/_article
dc.identifier.citationJournal of Oral Sciencees_ES
dc.identifier.issn1343-4934
dc.identifier.otherDOI: 10.2334/josnusd.17-0164
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/9236
dc.language.isoenes_ES
dc.publisherNihon University, School of Dentistryes_ES
dc.subjectDry mouthes_ES
dc.subjectMalic acides_ES
dc.subjectOral health-related quality of lifees_ES
dc.subjectXerostomiaes_ES
dc.titleImpact of 1% malic acid spray on the oral health-related quality of life of patients with xerostomiaes_ES
dc.typeArtículoes_ES
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