Estrogen signaling as a bridge between the nucleus and mitochondria in cardiovascular diseases

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dc.contributor.authorGuajardo-Correa, Emanuel
dc.contributor.authorSilva-Agüero, Juan Francisco
dc.contributor.authorCalle, Ximena
dc.contributor.authorChiong, Mario
dc.contributor.authorHenríquez, Mauricio
dc.contributor.authorGarcía-Rivas, Gerardo
dc.contributor.authorLatorre, Mauricio
dc.contributor.authorParra, Valentina
dc.date.accessioned2023-05-09T21:59:54Z
dc.date.available2023-05-09T21:59:54Z
dc.date.issued2022-09
dc.descriptionIndexación: Scopus.es
dc.description.abstractCardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Epidemiological studies indicate that pre-menopausal women are more protected against the development of CVDs compared to men of the same age. This effect is attributed to the action/effects of sex steroid hormones on the cardiovascular system. In this context, estrogen modulates cardiovascular function in physiological and pathological conditions, being one of the main physiological cardioprotective agents. Here we describe the common pathways and mechanisms by which estrogens modulate the retrograde and anterograde communication between the nucleus and mitochondria, highlighting the role of genomic and non-genomic pathways mediated by estrogen receptors. Additionally, we discuss the presumable role of bromodomain-containing protein 4 (BRD4) in enhancing mitochondrial biogenesis and function in different CVD models and how this protein could act as a master regulator of estrogen protective activity. Altogether, this review focuses on estrogenic control in gene expression and molecular pathways, how this activity governs nucleus-mitochondria communication, and its projection for a future generation of strategies in CVDs treatment.es
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fcell.2022.968373/full
dc.identifier.citationFrontiers in Cell and Developmental Biology. Volume 10. 14 September 2022. Article number 968373es
dc.identifier.doi10.3389/fcell.2022.968373
dc.identifier.issn2296-634X
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/49397
dc.language.isoenes
dc.publisherFrontiers Media S.A.es
dc.rights.licenseAtribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectEstrogenses
dc.subjectNucleuses
dc.subjectMitochondriaes
dc.subjectCardiovascular Diseaseses
dc.subjectCardiac Hypertrophyes
dc.subjectHeart Failurees
dc.titleEstrogen signaling as a bridge between the nucleus and mitochondria in cardiovascular diseaseses
dc.typeArtículoes
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