The role of the rodent insula in anxiety

Vista sencilla de ítem
dc.contributor.authorMéndez Ruette, Maxs
dc.contributor.authorLinsambarth, Sergio
dc.contributor.authorMoraga Amaro, Rodrigo
dc.contributor.authorQuintana Donoso, Daisy
dc.contributor.authorMéndez, Luis
dc.contributor.authorTamburini, Giovanni
dc.contributor.authorCornejo, Francisca
dc.contributor.authorTorres, Rodrigo F.
dc.contributor.authorStehberg, Jimmy
dc.date.accessioned2022-06-16T21:02:30Z
dc.date.available2022-06-16T21:02:30Z
dc.date.issued2019-03
dc.descriptionIndexación: Scopuses
dc.description.abstractThe human insula has been consistently reported to be overactivated in all anxiety disorders, activation which has been suggested to be proportional to the level of anxiety and shown to decrease with effective anxiolytic treatment. Nonetheless, studies evaluating the direct role of the insula in anxiety are lacking. Here, we set out to investigate the role of the rodent insula in anxiety by either inactivating different insular regions via microinjections of glutamatergic AMPA receptor antagonist CNQX or activating them by microinjection of GABA receptor antagonist bicuculline in rats, before measuring anxiety-like behavior using the elevated plus maze. Inactivation of caudal and medial insular regions induced anxiogenic effects, while their activation induced anxiolytic effects. In contrast, inactivation of more rostral areas induced anxiolytic effects and their activation, anxiogenic effects. These results suggest that the insula in the rat has a role in the modulation of anxiety-like behavior in rats, showing regional differences; rostral regions have an anxiogenic role, while medial and caudal regions have an anxiolytic role, with a transition area around bregma +0.5. The present study suggests that the insula has a direct role in anxiety. © 2019 Méndez-Ruette, Linsambarth, Moraga-Amaro, Quintana-Donoso, Méndez, Tamburini, Cornejo, Torres and Stehberg.es
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fphys.2019.00330/full
dc.identifier.citationFrontiers in Physiology Volume 10, Issue MAR2019 Article number 330es
dc.identifier.doi10.3389/fphys.2019.00330
dc.identifier.issn1664-042X
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/22870
dc.language.isoenes
dc.publisherFrontiers Media S.A.es
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectAnxietyes
dc.subjectBicucullinees
dc.subjectCNQXes
dc.subjectElevated plus mazees
dc.subjectInsulaes
dc.subjectInsular cortexes
dc.subjectRates
dc.titleThe role of the rodent insula in anxietyes
dc.typeArtículoes
Archivos
Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
Mendez_R_The_Role_of_Rodent_2019_Article.pdf
Tamaño:
2.3 MB
Formato:
Adobe Portable Document Format
Descripción:
TEXTO COMPLETO EN INGLES
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
FCE - Artículos de Revista