Inorganic polyphosphate as an energy source in tumorigenesis

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dc.contributor.authorBoyineni J.
dc.contributor.authorSredni S.T.
dc.contributor.authorMargaryan N.V.
dc.contributor.authorDemirkhanyan L.
dc.contributor.authorTye M.
dc.contributor.authorJohnson R.
dc.contributor.authorGonzalez-Nilo F.
dc.contributor.authorHendrix M.J.C.
dc.contributor.authorPavlov E.
dc.contributor.authorSoares M.B.
dc.contributor.authorZakharian E.
dc.contributor.authorMalchenko S.
dc.date.accessioned2021-08-04T17:43:46Z
dc.date.available2021-08-04T17:43:46Z
dc.date.issued2020-12
dc.descriptionIndexación Scopuses
dc.description.abstractCancer cells have high demands for energy to maintain their exceedingly proliferative growth. However, the mechanism of energy expenditure in cancer is not well understood. We hypothesize that cancer cells might utilize energy-rich inorganic polyphosphate (polyP), as energetic reserve. PolyP is comprised of orthophosphates linked by phosphoanhydride bonds, as in ATP. Here, we show that polyP is highly abundant in several types of cancer cells, including brain tumor-initiating cells (BTICs), i.e., stem-like cells derived from a mouse brain tumor model that we have previously described. The polymer is avidly consumed during starvation of the BTICs. Depletion of ATP by inhibiting glycolysis and mitochondrial ATP-synthase (OXPHOS) further decreases the levels of polyP and alters morphology of the cells. Moreover, enzymatic hydrolysis of the polymer impairs the viability of cancer cells and significantly deprives ATP stores. These results suggest that polyP might be utilized as a source of phosphate energy in cancer. While the role of polyP as an energy source is established for bacteria, this finding is the first demonstration that polyP may play a similar role in the metabolism of cancer cells. Copyright: © 2020 Boyineni et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.es
dc.description.urihttps://www.oncotarget.com/article/27838/text/
dc.identifier.citationOncotarget, Volume 11, Issue 50, Pages 4613 - 462415 December 2020es
dc.identifier.doi10.18632/ONCOTARGET.27838
dc.identifier.issn19492553
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/19650
dc.language.isoenes
dc.publisherImpact Journals LLCes
dc.subjectEnergy sourcees
dc.subjectGlycolysises
dc.subjectPolyphosphatees
dc.subjectMetabolismes
dc.subjectOXPHOSes
dc.titleInorganic polyphosphate as an energy source in tumorigenesises
dc.typeArtículoes
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