Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance
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Fecha
2022-12
Profesor/a Guía
Facultad/escuela
Idioma
en
Título de la revista
ISSN de la revista
Título del volumen
Editor
Nature Research
Nombre de Curso
Licencia CC
Attribution 4.0 International Deed (CC BY 4.0)
Licencia CC
https://creativecommons.org/licenses/by/4.0/
Resumen
Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019. We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking sequence revealed ARG-specific patterns of dispersal limitation and global transmission. Our data furthermore suggest certain geographies are more prone to transmission events and should receive additional attention. © 2022, The Author(s).
Notas
Indexación: Scopus
Palabras clave
Anti-Bacterial Agents, Drug Resistance, Bacterial, Genomics, Metagenome, Sewage, Sulfanilamide, Antiinfective Agent, Antimicrobial Resistance (AMR), Antibiotic ResistanceGenes (ARGs), Genomic Analysis
Citación
Nature Communications. Volume 13, Issue 1. December 2022. Article number 7251
DOI
10.1038/s41467-022-34312-7