Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance

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dc.contributor.authorMunk, Patrick
dc.contributor.authorBrinch, Christian
dc.contributor.authorMøller, Frederik Duus
dc.contributor.authorPetersen, Thomas N.
dc.contributor.authorHendriksen, Rene S.
dc.contributor.authorSeyfarth, Anne Mette
dc.contributor.authorKjeldgaard, Jette S.
dc.contributor.authorSvendsen, Christina Aaby
dc.contributor.authorvan Bunnik, Bram
dc.contributor.authorBerglund, Fanny
dc.contributor.authorBego, Artan
dc.contributor.authorPower, Pablo
dc.contributor.authorRees, Catherine
dc.contributor.authorLambrinidis, Dionisia
dc.contributor.authorNeilson, Elizabeth Heather Jakobsen
dc.contributor.authorGibb, Karen
dc.contributor.authorCoventry, Kris
dc.contributor.authorCollignon, Peter
dc.contributor.authorCassar, Susan
dc.contributor.authorAllerberger, Franz
dc.contributor.authorBegum, Anowara
dc.contributor.authorHossain, Zenat Zebin
dc.contributor.authorWorrell, Carlon
dc.contributor.authorVandenberg, Olivier
dc.contributor.authorPieters, Ilse
dc.contributor.authorVictorien, Dougnon Tamègnon
dc.contributor.authorSalazar Gutierrez, Angela Daniela
dc.contributor.authorSoria, Freddy
dc.contributor.authorGrujić, Vesna Rudić
dc.contributor.authorMazalica, Nataša
dc.contributor.authorRahube, Teddie O.
dc.contributor.authorTagliati, Carlos Alberto
dc.contributor.authorRodrigues, Dalia
dc.contributor.authorOliveira, Guilherme
dc.contributor.authorde Souza, Larissa Camila Ribeiro
dc.contributor.authorIvanov, Ivan
dc.contributor.authorJuste, Bonkoungou Isidore
dc.contributor.authorOumar, Traoré
dc.contributor.authorSopheak, Thet
dc.contributor.authorVuthy, Yith
dc.contributor.authorNgandijo, Antoinette
dc.contributor.authorNzouankeu, Ariane
dc.contributor.authorOlivier, Ziem A. Abah Jacques
dc.contributor.authorYost, Christopher K.
dc.contributor.authorKumar, Pratik
dc.contributor.authorBrar, Satinder Kaur
dc.contributor.authorTabo, Djim-Adjim
dc.contributor.authorAdell, Aiko D.
dc.contributor.authorParedes-Osses, Esteban
dc.contributor.authorMartinez, Maria Cristina
dc.contributor.authorSara, Cuadros-Orellana
dc.contributor.authorKe, Changwen
dc.contributor.authorZheng, Huanying
dc.contributor.authorBaisheng, Li
dc.contributor.authorLau, Lok Ting
dc.contributor.authorChung, Teresa
dc.contributor.authorJiao, Xiaoyang
dc.contributor.authorYu, Yongjie
dc.contributor.authorJiaYong, Zhao
dc.contributor.authorMorales, Johan F. Bernal
dc.contributor.authorValencia, Maria Fernanda
dc.contributor.authorDonado-Godoy, Pilar
dc.contributor.authorCoulibaly, Kalpy Julien
dc.contributor.authorHrenovic, Jasna
dc.contributor.authorJergović, Matijana
dc.contributor.authorKarpíšková, Renáta
dc.contributor.authorDeogratias, Zozo Nyarukweba
dc.contributor.authorElsborg, Bodil
dc.contributor.authorHansen, Lisbeth Truelstrup
dc.contributor.authorJensen, Pernille Erland
dc.contributor.authorAbouelnaga, Mohamed
dc.contributor.authorSalem, Mohamed Fathy
dc.contributor.authorKoolmeister, Marliin
dc.contributor.authorLegesse, Mengistu
dc.contributor.authorEguale, Tadesse
dc.contributor.authorHeikinheimo, Annamari
dc.contributor.authorLe Guyader, Soizick
dc.contributor.authorSchaeffer, Julien
dc.contributor.authorVillacis, Jose Eduardo
dc.contributor.authorSanneh, Bakary
dc.contributor.authorMalania, Lile
dc.contributor.authorNitsche, Andreas
dc.contributor.authorBrinkmann, Annika
dc.contributor.authorSchubert, Sara
dc.contributor.authorHesse, Sina
dc.contributor.authorBerendonk, Thomas U.
dc.contributor.authorSaba, Courage Kosi Setsoafia
dc.contributor.authorMohammed, Jibril
dc.contributor.authorFeglo, Patrick Kwame
dc.contributor.authorBanu, Regina Ama
dc.contributor.authorKotzamanidis, Charalampos
dc.contributor.authorLytras, Efthymios
dc.contributor.authorLickes, Sergio A.
dc.contributor.authorKocsis, Bela
dc.contributor.authorSolymosi, Norbert
dc.contributor.authorThorsteinsdottir, Thorunn R.
dc.contributor.authorHatha, Abdulla Mohamed
dc.contributor.authorBallal, Mamatha
dc.contributor.authorBangera, Sohan Rodney
dc.contributor.authorFani, Fereshteh
dc.contributor.authorAlebouyeh, Masoud
dc.contributor.authorMorris, Dearbhaile
dc.contributor.authorO’Connor, Louise
dc.contributor.authorCormican, Martin
dc.contributor.authorMoran-Gilad, Jacob
dc.contributor.authorBattisti, Antonio
dc.contributor.authorDiaconu, Elena Lavinia
dc.contributor.authorCorno, Gianluca
dc.contributor.authorDi Cesare, Andrea
dc.contributor.authorAlba, Patricia
dc.contributor.authorHisatsune, Junzo
dc.contributor.authorYu, Liansheng
dc.contributor.authorKuroda, Makoto
dc.contributor.authorSugai, Motoyuki
dc.contributor.authorKayama, Shizuo
dc.contributor.authorShakenova, Zeinegul
dc.contributor.authorKiiyukia, Ciira
dc.contributor.authorNg’eno, Eric
dc.contributor.authorRaka, Lul
dc.contributor.authorJamil, Kazi
dc.contributor.authorFakhraldeen, Saja Adel
dc.contributor.authorAlaati, Tareq
dc.contributor.authorBērziņš, Aivars
dc.contributor.authorAvsejenko, Jeļena
dc.contributor.authorKokina, Kristina
dc.contributor.authorStreikisa, Madara
dc.contributor.authorBartkevics, Vadims
dc.contributor.authorMatar, Ghassan M.
dc.contributor.authorDaoud, Ziad
dc.contributor.authorPereckienė, Asta
dc.contributor.authorButrimaite-Ambrozeviciene, Ceslova
dc.contributor.authorPenny, Christian
dc.contributor.authorBastaraud, Alexandra
dc.contributor.authorRasolofoarison, Tiavina
dc.contributor.authorCollard, Jean-Marc
dc.contributor.authorSamison, Luc Hervé
dc.contributor.authorAndrianarivelo, Mala Rakoto
dc.contributor.authorBanda, Daniel Lawadi
dc.contributor.authorAmin, Arshana
dc.contributor.authorRajandas, Heraa
dc.contributor.authorParimannan, Sivachandran
dc.contributor.authorSpiteri, David
dc.contributor.authorHaber, Malcolm Vella
dc.contributor.authorSantchurn, Sunita J.
dc.contributor.authorVujacic, Aleksandar
dc.contributor.authorDjurovic, Dijana
dc.contributor.authorBouchrif, Brahim
dc.contributor.authorKarraouan, Bouchra
dc.contributor.authorVubil, Delfino Carlos
dc.contributor.authorPal, Pushkar
dc.contributor.authorSchmitt, Heike
dc.contributor.authorvan Passel, Mark
dc.contributor.authorJeunen, Gert-Jan
dc.contributor.authorGemmell, Neil
dc.contributor.authorChambers, Stephen T.
dc.contributor.authorMendoza, Fania Perez
dc.contributor.authorHuete-Pιrez, Jorge
dc.contributor.authorVilchez, Samuel
dc.contributor.authorAhmed, Akeem Olayiwola
dc.contributor.authorAdisa, Ibrahim Raufu
dc.contributor.authorOdetokun, Ismail Ayoade
dc.contributor.authorFashae, Kayode
dc.contributor.authorSørgaard, Anne-Marie
dc.contributor.authorWester, Astrid Louise
dc.contributor.authorRyrfors, Pia
dc.contributor.authorHolmstad, Rune
dc.contributor.authorMohsin, Mashkoor
dc.contributor.authorHasan, Rumina
dc.contributor.authorShakoor, Sadia
dc.contributor.authorGustafson, Natalie Weiler
dc.contributor.authorSchill, Claudia Huber
dc.contributor.authorRojas, Maria Luz Zamudio
dc.contributor.authorVelasquez, Jorge Echevarria
dc.contributor.authorMagtibay, Bonifacio B.
dc.contributor.authorCatangcatang, Kris
dc.contributor.authorSibulo, Ruby
dc.contributor.authorYauce, Felipe Campos
dc.contributor.authorWasyl, Dariusz
dc.contributor.authorManaia, Celia
dc.contributor.authorRocha, Jaqueline
dc.contributor.authorMartins, Jose
dc.contributor.authorÁlvaro, Pedro
dc.contributor.authorDi Yoong Wen, Doris
dc.contributor.authorShin, Hanseob
dc.contributor.authorHur, Hor-Gil
dc.contributor.authorYoon, Sukhwan
dc.contributor.authorBosevska, Golubinka
dc.contributor.authorKochubovski, Mihail
dc.contributor.authorCojocaru, Radu
dc.contributor.authorBurduniuc, Olga
dc.contributor.authorHong, Pei-Ying
dc.contributor.authorPerry, Meghan Rose
dc.contributor.authorGassama, Amy
dc.contributor.authorRadosavljevic, Vladimir
dc.contributor.authorTay, Moon Y. F.
dc.contributor.authorZuniga-Montanez, Rogelio
dc.contributor.authorWuertz, Stefan
dc.contributor.authorGavačová, Dagmar
dc.contributor.authorPastuchová, Katarína
dc.contributor.authorTruska, Peter
dc.contributor.authorTrkov, Marija
dc.contributor.authorKeddy, Karen
dc.contributor.authorEsterhuyse, Kerneels
dc.contributor.authorSong, Min Joon
dc.contributor.authorQuintela-Baluja, Marcos
dc.contributor.authorLopez, Mariano Gomez
dc.contributor.authorCerdà-Cuéllar, Marta
dc.contributor.authorPerera R.R.D.P.
dc.contributor.authorBandara N.K.B.K.R.G.W.
dc.contributor.authorPremasiri H.I.
dc.contributor.authorPathirage, Sujatha
dc.contributor.authorCharlemagne, Kareem
dc.contributor.authorRutgersson, Carolin
dc.contributor.authorNorrgren, Leif
dc.contributor.authorÖrn, Stefan
dc.contributor.authorBoss, Renate
dc.contributor.authorVan der Heijden, Tanja
dc.contributor.authorHong, Yu-Ping
dc.contributor.authorKumburu, Happiness Houka
dc.contributor.authorMdegela, Robinson Hammerthon
dc.contributor.authorHounmanou, Yaovi Mahuton Gildas
dc.contributor.authorChonsin, Kaknokrat
dc.contributor.authorSuthienkul, Orasa
dc.contributor.authorThamlikitkul, Visanu
dc.contributor.authorde Roda Husman, Ana Maria
dc.contributor.authorBidjada, Bawimodom
dc.contributor.authorNjanpop-Lafourcade, Berthe-Marie
dc.contributor.authorNikiema-Pessinaba, Somtinda Christelle
dc.contributor.authorLevent, Belkis
dc.contributor.authorKurekci, Cemil
dc.contributor.authorEjobi, Francis
dc.contributor.authorKalule, John Bosco
dc.contributor.authorThomsen, Jens
dc.contributor.authorObaidi, Ouidiane
dc.contributor.authorJassim, Laila Mohamed
dc.contributor.authorMoore, Andrew
dc.contributor.authorLeonard, Anne
dc.contributor.authorGraham, David W.
dc.contributor.authorBunce, Joshua T.
dc.contributor.authorZhang, Lihong
dc.contributor.authorGaze, William H.
dc.contributor.authorLefor, Brett
dc.contributor.authorCapone, Drew
dc.contributor.authorSozzi, Emanuele
dc.contributor.authorBrown, Joe
dc.contributor.authorMeschke, John Scott
dc.contributor.authorSobsey, Mark D.
dc.contributor.authorDavis, Michael
dc.contributor.authorBeck, Nicola Koren
dc.contributor.authorSukapanpatharam, Pardi
dc.contributor.authorTruong, Phuong
dc.contributor.authorLilienthal, Ronald
dc.contributor.authorKang, Sanghoon
dc.contributor.authorWittum, Thomas E.
dc.contributor.authorRigamonti, Natalia
dc.contributor.authorBaklayan, Patricia
dc.contributor.authorVan, Chinh Dang
dc.contributor.authorTran, Doan Minh Nguyen
dc.contributor.authorDo Phuc, Nguyen
dc.contributor.authorKwenda, Geoffrey
dc.contributor.authorLarsson, D. G. Joakim
dc.contributor.authorKoopmans, Marion
dc.contributor.authorWoolhouse, Mark
dc.contributor.authorAarestrup, Frank M.
dc.date.accessioned2025-04-17T17:37:39Z
dc.date.available2025-04-17T17:37:39Z
dc.date.issued2022-12
dc.descriptionIndexación: Scopus
dc.description.abstractAntimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019. We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking sequence revealed ARG-specific patterns of dispersal limitation and global transmission. Our data furthermore suggest certain geographies are more prone to transmission events and should receive additional attention. © 2022, The Author(s).
dc.description.urihttps://www-nature-com.recursosbiblioteca.unab.cl/articles/s41467-022-34312-7
dc.identifier.citationNature Communications. Volume 13, Issue 1. December 2022. Article number 7251
dc.identifier.doi10.1038/s41467-022-34312-7
dc.identifier.issn2041-1723
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/64222
dc.language.isoen
dc.publisherNature Research
dc.rights.licenseAttribution 4.0 International Deed (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAnti-Bacterial Agents
dc.subjectDrug Resistance
dc.subjectBacterial
dc.subjectGenomics
dc.subjectMetagenome
dc.subjectSewage
dc.subjectSulfanilamide
dc.subjectAntiinfective Agent
dc.subjectAntimicrobial Resistance (AMR)
dc.subjectAntibiotic ResistanceGenes (ARGs)
dc.subjectGenomic Analysis
dc.titleGenomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance
dc.typeArtículo
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