Study on the cytotoxic activity of drimane sesquiterpenes and nordrimane compounds against cancer cell lines

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dc.contributor.authorMontenegro, Ivan
dc.contributor.authorTomasoni, Giacomo
dc.contributor.authorBosio, Claudia
dc.contributor.authorQuiñones, Natalia
dc.contributor.authorMadrid, Alejandro
dc.contributor.authorCarrasco, Hector
dc.contributor.authorOlea, Andres
dc.contributor.authorMartinez, Rolando
dc.contributor.authorCuellar, Mauricio
dc.contributor.authorVillena, Joan
dc.date.accessioned2023-01-03T18:35:55Z
dc.date.available2023-01-03T18:35:55Z
dc.date.issued2014
dc.descriptionIndexación: Scopuses
dc.description.abstractTwelve drimanes, including polygodial (1), isopolygodial (2), drimenol (3), confertifolin (4), and isodrimenin (5), were obtained from natural sources. Semi-synthetic derivatives 6-12 were obtained from 1 and 2, and cytotoxic activity was evaluated in vitro against cancer cell lines (HT-29, MDA-MB231, DHF, MCF-7, PC-3, DU-145, and CoN). IC50 values were determined at concentrations of 12.5-100 ìM of each compound for 72 h. In addition, it was found that polygodial (1), 8, and 12 induced changes in mitochondrial membrane permeability in CoN, MCF-7, and PC-3 cells. © 2014 by the authors.es
dc.description.urihttps://www.mdpi.com/1420-3049/19/11/18993
dc.identifier.doi10.3390/molecules191118993
dc.identifier.issn1420-3049
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/35776
dc.language.isoenes
dc.publisherMDPI AGes
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectApoptosises
dc.subjectCancer cell lineses
dc.subjectCaspasa-3 activityes
dc.subjectCytotoxic activityes
dc.subjectDrimaneses
dc.subjectMitochondrial membrane permeabilityes
dc.subjectNordrimaneses
dc.subjectSesquiterpeneses
dc.titleStudy on the cytotoxic activity of drimane sesquiterpenes and nordrimane compounds against cancer cell lineses
dc.typeArtículoes
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Molecules Volume 19, Issue 11, Pages 18993 - 190061 November 2014
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