Photochemistry of P,N-bidentate rhenium(i) tricarbonyl complexes: Reactive species generation and potential application for antibacterial photodynamic therapy

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dc.contributor.authorAcosta, Alison
dc.contributor.authorAntipán, Javier
dc.contributor.authorFernández, Mariano
dc.contributor.authorPrado, Gaspar
dc.contributor.authorSandoval-Altamirano, Catalina
dc.contributor.authorGünther, Germán
dc.contributor.authorGutiérrez-Urrutia, Izabook
dc.contributor.authorPoblete-Castro, Ignacio
dc.contributor.authorVega, Andrés
dc.contributor.authorPizarro, Nancy
dc.date.accessioned2023-07-19T13:56:26Z
dc.date.available2023-07-19T13:56:26Z
dc.date.issued2021-09
dc.descriptionIndexación: Scopuses
dc.description.abstractIn this work, we describe the photoisomerization of facial rhenium(i) tricarbonyl complexes bearing P,N-bidentate pyridyl/phosphine ligands with different chelating rings and anions: RePNBr, RePNTfO, and RePNNBr, which are triggered under irradiation at 365 nm in solutions. The apparent photodegradation rate constants (kapp) depend on the coordinating ability of the solvent, being lowest in acetonitrile. The kapp value increases as the temperature rises, suggesting a reactive IL excited state thermally populated from the MLCT excited state involved. Using the Eyring equation, positive activation enthalpies (ΔH≠) accompanied by high negative values for the activation entropy (ΔS≠) were obtained. These results suggest whatever the P,N-ligand or anion, the reaction proceeds through a strongly solvated or a compact transition state, which is compatible with an associative mechanism for the photoisomerization. A 100-fold decrease in the log10 CFU value is observed for E. coli and S. aureus in irradiated solutions of the compounds, which follows the same tendency as their singlet oxygen generation quantum yield: RePNBr > RePNTfO > RePNNBr, while no antibacterial activity is observed in the darkness. This result indicates that the generation of singlet oxygen plays a key role in the antibacterial capacity of these complexes. © The Royal Society of Chemistry.es
dc.description.urihttps://www-scopus-com.recursosbiblioteca.unab.cl/record/display.uri?eid=2-s2.0-85120053842&origin=resultslist&sort=plf-f&src=s&sid=54b557906a065656dad1ee12398bb332&sot=b&sdt=b&s=TITLE-ABS-KEY%28photochemistry+AND+of+AND+p%2Cn-bidentate+AND+rhenium+i+tricarbonyl+AND+complexes%3A+AND+reactive+AND+species+AND+generation+AND+potential+AND+application+AND+for+AND+antibacterial+AND+photodynamic+AND+therapy%29&sl=173&sessionSearchId=54b557906a065656dad1ee12398bb332
dc.identifier.citationRSC Advances Open Access Volume 11, Issue 51, Pages 31959 - 3196614 September 2021es
dc.identifier.doi10.1039/d1ra06416a
dc.identifier.issn20462069
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/51784
dc.language.isoenes
dc.publisherRoyal Society of Chemistryes
dc.rights.licenseAttribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/
dc.subjectChemical activationes
dc.subjectExcited stateses
dc.subjectGas generatorses
dc.subjectLigandses
dc.subjectNegative ionses
dc.subjectOrganic solventses
dc.subjectOxygenes
dc.subjectPhotodynamic therapyes
dc.subjectRate constantses
dc.titlePhotochemistry of P,N-bidentate rhenium(i) tricarbonyl complexes: Reactive species generation and potential application for antibacterial photodynamic therapyes
dc.typeArtículoes
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