AsociaciĆ³n entre virus Papiloma Humano16 y carcinoma oral de celulas escamosas : una revisiĆ³n de alcance
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2022
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es
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Universidad AndrƩs Bello
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Licencia CC
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IntroducciĆ³n: La prevalencia estimada del cĆ”ncer oral en el aƱo 2020 segĆŗn GLOBOCAN
fue de 377.713 casos a nivel mundial, posicionƔndose entre los cƔnceres mƔs comunes
de la regiĆ³n de cabeza y cuello; siendo el carcinoma oral de cĆ©lulas escamosas (COCE)
la neoplasia maligna mĆ”s comĆŗn de la cavidad oral. Existen aproximadamente 200
genotipos de VPH; sin embargo, la mayorĆa de los cĆ”nceres de la orofaringe (Ć³rgano
contiguo a la cavidad oral) estƔn asociados con el genotipo 16. Estudios han sugerido
que se continĆŗe abordando la asociaciĆ³n entre COCE y VPH-16. Objetivo principal:
Describir segĆŗn la evidencia cientĆfica la asociaciĆ³n entre el virus papiloma humano16 y
cĆ”ncer oral de cĆ©lulas escamosas. MetodologĆa: Se realizĆ³ una bĆŗsqueda de evidencia a
travĆ©s de una revisiĆ³n de alcance (Scoping Review) en la base de datos PubMed;
utilizando las palabras claves seleccionadas y ajustadas por las opciones del buscador y
empleando una serie de criterios de inclusiĆ³n y exclusiĆ³n para filtrar los estudios. Se
organizĆ³ la evidencia disponible para facilitar la selecciĆ³n final de artĆculos. Los datos
fueron estandarizados y luego sintetizados de forma narrativa. Se utilizĆ³ el modelo IMRyD
y considerando el uso de PRIMSA ScR para realizar el estudio. Resultados: De un total
de 306 artĆculos, se incluyeron 17 en el presente estudio; provenientes en su mayorĆa del
continente asiĆ”tico. Se concluyĆ³ que las investigaciones sugieren que continĆŗa existiendo
un dĆ©ficit en la evidencia con respecto a la asociaciĆ³n efectiva entre el COCE y la
infecciĆ³n por VPH-16 y que la utilizaciĆ³n del marcador p16 incurre en la determinaciĆ³n
de falsos positivos de casos de COCE relacionados al VPH-16.
Introduction: The estimated prevalence of oral cancer in 2020 according to GLOBOCAN was 377,713 cases worldwide, ranking among the most common cancers in the head and neck region; being oral squamous cell carcinoma (OCCE) the most common malignant neoplasm of the oral cavity. There are approximately 200 HPV genotypes; however, most cancers of the oropharynx (organ adjacent to the oral cavity) are associated with genotype 16. Studies have suggested that the association between OCCE and HPV-16 continue to be addressed. Main objective: To describe, according to scientific evidence, the association between human papillomavirus 16 and oral squamous cell cancer. Methodology: A search for evidence was carried out through a Scoping Review in the PubMed database; using the keywords selected and adjusted by the search engine options and using a series of inclusion and exclusion criteria to filter the studies. The available evidence was organized to facilitate the final selection of articles. The data was standardized and then synthesized in a narrative way. The IMRyD model was used and considering the use of PRIMSA ScR to carry out the study. Results and conclusions: Of a total of 307 articles, 17 were included in the present study; mostly from the Asian continent. It was concluded that the investigations suggest that there is still a lack of evidence regarding the effective association between OCCE and HPV-16 infection and that the use of the p16 marker incurs in the determination of false positives in cases of OCCE related to HPV-16.
Introduction: The estimated prevalence of oral cancer in 2020 according to GLOBOCAN was 377,713 cases worldwide, ranking among the most common cancers in the head and neck region; being oral squamous cell carcinoma (OCCE) the most common malignant neoplasm of the oral cavity. There are approximately 200 HPV genotypes; however, most cancers of the oropharynx (organ adjacent to the oral cavity) are associated with genotype 16. Studies have suggested that the association between OCCE and HPV-16 continue to be addressed. Main objective: To describe, according to scientific evidence, the association between human papillomavirus 16 and oral squamous cell cancer. Methodology: A search for evidence was carried out through a Scoping Review in the PubMed database; using the keywords selected and adjusted by the search engine options and using a series of inclusion and exclusion criteria to filter the studies. The available evidence was organized to facilitate the final selection of articles. The data was standardized and then synthesized in a narrative way. The IMRyD model was used and considering the use of PRIMSA ScR to carry out the study. Results and conclusions: Of a total of 307 articles, 17 were included in the present study; mostly from the Asian continent. It was concluded that the investigations suggest that there is still a lack of evidence regarding the effective association between OCCE and HPV-16 infection and that the use of the p16 marker incurs in the determination of false positives in cases of OCCE related to HPV-16.
Notas
Tesis (Cirujano Dentista)
Palabras clave
CƔncer de Boca, Papillomavirus, Carcinoma de CƩlulas Escamosas, Investigaciones