DNA, cell wall and general oxidative damage underlie the tellurite/cefotaxime synergistic effect in Escherichia coli

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dc.contributor.authorMolina-Quiroz, R.
dc.contributor.authorLoyola, D.
dc.contributor.authorMuñoz-Villagrán, C.
dc.contributor.authorQuatrini, R.
dc.contributor.authorVásquez, C.
dc.contributor.authorPérez-Donoso, J.
dc.date.accessioned2023-04-04T15:49:39Z
dc.date.available2023-04-04T15:49:39Z
dc.date.issued2013-11
dc.descriptionIndexación: Scopus.
dc.description.abstractThe constant emergence of antibiotic multi-resistant pathogens is a concern worldwide. An alternative for bacterial treatment using nM concentrations of tellurite was recently proposed to boost antibiotic-toxicity and a synergistic effect of tellurite/cefotaxime (CTX) was described. In this work, the molecular mechanism underlying this phenomenon is proposed. Global changes of the transcriptional profile of Escherichia coli exposed to tellurite/CTX were determined by DNA microarrays. Induction of a number of stress regulators (as SoxS), genes related to oxidative damage and membrane transporters was observed. Accordingly, increased tellurite adsorption/uptake and oxidative injuries to proteins and DNA were determined in cells exposed to the mixture of toxicants, suggesting that the tellurite-mediated CTX-potentiating effect is dependent, at least in part, on oxidative stress. Thus, the synergistic tellurite-mediated CTX-potentiating effect depends on increased tellurite uptake/adsorption which results in damage to proteins, DNA and probably other macromolecules. Our findings represent a contribution to the current knowledge of bacterial physiology under antibiotic stress and can be of great interest in the development of new antibiotic-potentiating strategies.es
dc.description.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0079499
dc.identifier.citationPLoS ONE, Volume 8, Issue 1118, November 2013, Article number e79499es
dc.identifier.doi10.1371/journal.pone.0079499
dc.identifier.issn1932-6203
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/48174
dc.language.isoenes
dc.publisherPublic Library of Sciencees
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://journals.plos.org/plosone/s/journal-information#loc-open-access
dc.subjectAnti-Bacterial Agentses
dc.subjectCefotaximees
dc.subjectCell Walles
dc.subjectEscherichia colies
dc.subjectTelluriumes
dc.titleDNA, cell wall and general oxidative damage underlie the tellurite/cefotaxime synergistic effect in Escherichia colies
dc.typeArtículoes
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