The Incubation of 13α,17-Dihydroxystemodane with Cephalosporium aphidicola
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Fecha
2012-02
Profesor/a Guía
Facultad/escuela
Idioma
en
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Título del volumen
Editor
MDPI AG
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Licencia CC
Attribution 4.0 International (CC BY 4.0)
Licencia CC
https://www.mdpi.com/openaccess
Resumen
The biotransformation of 13α,17-dihydroxystemodane (3) with the fungus Cephalosporium aphidicola afforded 13α,17,18-trihydroxystemodane (4), 3β,13α,17-trihydroxystemodane (5), 13α,17-dihydroxy- stemodan-18-oic acid (6), 3β,11β,13α,17-tetrahydroxystemodane (7), 11β,13α,17,18-tetrahydroxystemodane (8) and 3β,13α, 17,18-tetrahydroxystemodane (9). The hydroxylation at C-18 of the substrate points to a biosynthetically-directed transformation, because aphidicolin (2) is hydroxylated at this carbon. However, the C-3(β) and C-11(β) hydroxylations seem to indicate a xenobiotic biotransformation.
Notas
Indexación: Scopus.
Palabras clave
Biotransformations, Cephalosporium aphidicola, Diterpenes, Stemodane
Citación
Molecules, Volume 17, Issue 2, Pages 1744 - 1750, February 2012
DOI
10.3390/molecules17021744