Characterization of an agarophyton chilense oleoresin containing pparĪ³ natural ligands with insulin-sensitizing effects in a c57bl/6j mouse model of diet-induced obesity and antioxidant activity in caenorhabditis elegans

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dc.contributor.authorPinto, Claudio
dc.contributor.authorIbƔƱez, Marƭa Raquel
dc.contributor.authorLoyola, Gloria
dc.contributor.authorLeĆ³n, Luisa
dc.contributor.authorSalvatore, Yasmin
dc.contributor.authorGonzƔlez, Carla
dc.contributor.authorBarraza, VĆ­ctor
dc.contributor.authorCastaƱeda, Francisco
dc.contributor.authorAldunate, Rebeca
dc.contributor.authorContreras Porcia, Loretto
dc.contributor.authorFuenzalida, Karen
dc.contributor.authorBronfman, Francisca C.
dc.date.accessioned2022-09-05T23:11:19Z
dc.date.available2022-09-05T23:11:19Z
dc.date.issued2021-05
dc.descriptionIndexaciĆ³n: Scopuses
dc.description.abstractThe biomedical potential of the edible red seaweed Agarophyton chilense (formerly Gracilaria chilensis) has not been explored. Red seaweeds are enriched in polyunsaturated fatty acids and eicosanoids, which are known natural ligands of the PPARĪ³ nuclear receptor. PPARĪ³ is the molecular target of thiazolidinediones (TZDs), drugs used as insulin sensitizers to treat type 2 diabetes mellitus. Medical use of TZDs is limited due to undesired side effects, a problem that has triggered the search for selective PPARĪ³ modulators (SPPARMs) without the TZD side effects. We produced Agarophyton chilense oleoresin (GracilexĀ®), which induces PPARĪ³ activation without in-ducing adipocyte differentiation, similar to SPPARMs. In a diet-induced obesity model of male mice, we showed that treatment with GracilexĀ® improves insulin sensitivity by normalizing altered glucose and insulin parameters. GracilexĀ® is enriched in palmitic acid, arachidonic acid, oleic acid, and lipophilic antioxidants such as tocopherols and Ī²-carotene. Accordingly, GracilexĀ® possesses antioxidant activity in vitro and increased antioxidant capacity in vivo in Caenorhabditis elegans. These findings support the idea that GracilexĀ® represents a good source of natural PPARĪ³ ligands and antioxidants with the potential to mitigate metabolic disorders. Thus, its nutraceutical value in humans warrants further investigation. Ā© 2021 by the author. Licensee MDPI, Basel, Switzerland.es
dc.description.urihttps://www.mdpi.com/2072-6643/13/6/1828
dc.identifier.citationNutrients Volume 13, Issue 6June 2021 Article number 1828es
dc.identifier.doi10.3390/nu13061828
dc.identifier.issn2072-6643
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/23758
dc.language.isoenes
dc.publisherMDPIes
dc.rights.licenseAtribuciĆ³n 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectAgarophyton chilensees
dc.subjectAnti-oxidantses
dc.subjectCaenorhabditis eleganses
dc.subjectGracilexĀ®es
dc.subjectInsulin resistancees
dc.subjectNatural lipidses
dc.subjectPPARĪ³es
dc.titleCharacterization of an agarophyton chilense oleoresin containing pparĪ³ natural ligands with insulin-sensitizing effects in a c57bl/6j mouse model of diet-induced obesity and antioxidant activity in caenorhabditis eleganses
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