Synthesis and evaluation of new heteroaryl nitrones with spin trap properties

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dc.contributor.authorBarriga-González G.
dc.contributor.authorAliaga C.
dc.contributor.authorChamorro E.
dc.contributor.authorOlea-Azar C.
dc.contributor.authorNorambuena E.
dc.contributor.authorPorcal W.
dc.contributor.authorGonzález M.
dc.contributor.authorCerecetto H.
dc.date.accessioned2021-11-04T18:42:45Z
dc.date.available2021-11-04T18:42:45Z
dc.date.issued2020-11
dc.descriptionIndexación Scopuses
dc.description.abstractA new series of heteroaryl nitrones were synthesized and evaluated as free radical traps due to the results showed in our previous report. The physicochemical characterization of these new nitrones by electron spin resonance (ESR) demonstrated their high capability to trap and stabilize different atom centered free radicals generated by the Fenton reaction. Additionally, we intensely studied them in terms of their physicochemical properties. Kinetic studies, including the use of a method based on competition and the hydroxyl adduct decay, gave the corresponding rate constants and half-lives at the physiological pH of these newly synthesized nitrones. New nitrones derived from quinoxaline 1,4-dioxide heterocycles were more suitable than DMPO to trap hydroxyl free radicals with a half-life longer than two hours. We explain some of the results using computational chemistry through density functional theory (DFT). © 2020 The Royal Society of Chemistry.es
dc.description.urihttps://pubs.rsc.org/en/content/articlelanding/2020/RA/D0RA07720H
dc.identifier.citationRSC Advances, Volume 10, Issue 66, Pages 40127 - 40135November 2020es
dc.identifier.doi10.1039/d0ra07720h
dc.identifier.issn20462069
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/20747
dc.language.isoenes
dc.publisherRoyal Society of Chemistryes
dc.subjectSpin Trappinges
dc.subjectNitroneses
dc.subjectPhenyl-N-Tert-Butylnitronees
dc.titleSynthesis and evaluation of new heteroaryl nitrones with spin trap propertieses
dc.typeArtículoes
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