The Anti-Oxidant Curcumin Solubilized as Oil-in-Water Nanoemulsions or Chitosan Nanocapsules Effectively Reduces Helicobacter pylori Growth, Bacterial Biofilm Formation, Gastric Cell Adhesion and Internalization

Vista sencilla de ítem
dc.contributor.authorHidalgo, Antonio
dc.contributor.authorBravo, Denisse
dc.contributor.authorSoto, Cristopher
dc.contributor.authorMaturana, Gabriela
dc.contributor.authorCordero-Machuca, Jimena
dc.contributor.authorZúñiga-López, María Carolina
dc.contributor.authorOyarzun-Ampuero, Felipe
dc.contributor.authorQuest, Andrew F. G.
dc.date.accessioned2023-12-05T15:01:47Z
dc.date.available2023-12-05T15:01:47Z
dc.date.issued2023
dc.descriptionIndexación: Scopus.es
dc.description.abstractThe bacterium Helicobacter pylori (H. pylori) represents a major risk factor associated with the development of gastric cancer. The anti-oxidant curcumin has been ascribed many benefits to human health, including bactericidal effects. However, these effects are poorly reproducible because the molecule is extremely unstable and water insoluble. Here we solubilized curcumin as either nanoemulsions or chitosan nanocapsules and tested the effects on H. pylori. The nanoemulsions were on average 200 nm in diameter with a PdI ≤ 0.16 and a negative zeta potential (−54 mV), while the nanocapsules were 305 nm in diameter with a PdI ≤ 0.29 and a positive zeta potential (+68 mV). Nanocapsules were safer than nanoemulsions when testing effects on the viability of GES-1 gastric cells. Also, nanocapsules were more efficient than nanoemulsions at inhibiting H. pylori growth (minimal inhibitory concentration: 50 and 75 μM, respectively), whereby chitosan contributed to this activity. Importantly, both formulations effectively diminished H. pylori’s adherence to and internalization by GES-1 cells, as well as biofilm formation. In summary, the demonstrated activity of the curcumin nanoformulations described here against H. pylori posit them as having great potential to treat or complement other therapies currently in use against H. pylori infection.es
dc.description.urihttps://www-scopus-com.recursosbiblioteca.unab.cl/record/display.uri?eid=2-s2.0-85175450795&origin=resultslist&sort=plf-f&src=s&nlo=&nlr=&nls=&sid=78c123ff315876e60d18d87d504fe9f1&sot=aff&sdt=cl&cluster=scofreetoread%2c%22all%22%2ct&sl=34&s=AF-ID%2860002636%29+AND+SUBJAREA%28BIOC%29&relpos=14&citeCnt=0&searchTerm=
dc.identifier.citationAntioxidants Open Access Volume 12, Issue 10 October 2023 Article number 1866es
dc.identifier.doi10.3390/antiox12101866
dc.identifier.issn20763921
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/54402
dc.language.isoenes
dc.publisherMDPIes
dc.rights.licenseCC BY 4.0 DEED
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCurcumines
dc.subjectGastric canceres
dc.subjectHelicobacter pylories
dc.subjectNanocapsuleses
dc.subjectNanoemulsionses
dc.subjectToxicityes
dc.titleThe Anti-Oxidant Curcumin Solubilized as Oil-in-Water Nanoemulsions or Chitosan Nanocapsules Effectively Reduces Helicobacter pylori Growth, Bacterial Biofilm Formation, Gastric Cell Adhesion and Internalizationes
dc.typeArtículoes
Archivos
Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
Hidalgo- A.-The-AntiOxidant-Curcumin-Solubilized-as-OilinWater-Nanoemulsions-or-Chitosan-Nanocapsules-Effectively-Reduces-Helicobacter-pylori-Growth-Bacterial-Biofilm-Formation-Gastric-Cell-Adhesion-and-Internalization.pdf
Tamaño:
3.08 MB
Formato:
Adobe Portable Document Format
Descripción:
TEXTO COMPLETO EN INGLES
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
FO - Artículos de Revista