Seco-taondiol, an unusual meroterpenoid from the Chilean seaweed Stypopodium flabelliforme and its gastroprotective effect in mouse model

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dc.contributor.authorAreche, Carlos
dc.contributor.authorBenites, Julio
dc.contributor.authorCornejo, Alberto
dc.contributor.authorRuiz, Lina M.
dc.contributor.authorGarcía-Beltrán, Olimpo
dc.contributor.authorSimirgiotis, Mario J.
dc.contributor.authorSepúlveda, Beatriz
dc.date.accessioned2023-06-22T18:59:23Z
dc.date.available2023-06-22T18:59:23Z
dc.date.issued2015-04
dc.descriptionIndexación: Scopus.es
dc.description.abstractTen known meroterpenoids and the new meroterpenoid 7 were isolated from the Chilean seaweed Stypopodium flabelliforme as their acetylated derivatives. Furthermore, the known metabolite taondiol has been isolated for the first time from this species. The molecular structure of the new metabolite was determined by spectroscopic methods based on 1D- and 2D-NMR. Isolation of 7 represents a key step toward a better understanding of the biogenesis of this class of meroterpenoids. Among the meroditerpenoids isolated, stypodiol, isoepitaondiol, epitaondiol and sargaol exhibited gastroprotective activity on the HCl/Ethanol-induced gastric lesions model in mice. Regarding the mode of gastroprotective action, the activity of epitaondiol was reversed significantly when animals were pretreated with indomethacin, N-ethylmaleimide and N-nitro-l-arginine methyl ester (L-NAME) suggesting that prostaglandins, sulfhydryl groups and nitric oxide are involved in their mode of gastroprotective action. In the case of sargaol the gastroprotective activity was attenuated with indomethacin and N-ethylmaleimide, which suggests that prostaglandins and sulfhydryl groups are also involved in the mode of action using this model.es
dc.description.urihttps://www.mdpi.com/1660-3397/13/4/1726
dc.identifier.citationMarine Drugs. Volume 13, Issue 4, Pages 1726 - 1738. 1 April 2015es
dc.identifier.doi10.3390/md13041726
dc.identifier.issn1660-3397
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/50975
dc.language.isoenes
dc.publisherMDPI AGes
dc.rights.licenseAtribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectStypopodium Fabelliformees
dc.subjectMeroditerpenoidses
dc.subjectGastroprotectivees
dc.subjectGastric Ulceres
dc.subjectSeaweedes
dc.titleSeco-taondiol, an unusual meroterpenoid from the Chilean seaweed Stypopodium flabelliforme and its gastroprotective effect in mouse modeles
dc.typeArtículoes
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