Levels of the interleukins 17A, 22, and 23 and the S100 protein family in the gingival crevicular fluid of psoriatic patients with or without periodontitis

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dc.contributor.authorJiménez, C.
dc.contributor.authorCarvajal, D.
dc.contributor.authorHernández, M.
dc.contributor.authorValenzuela, F.
dc.contributor.authorAstorga, J.
dc.contributor.authorFernández, A.
dc.date.accessioned2024-09-11T13:47:20Z
dc.date.available2024-09-11T13:47:20Z
dc.date.issued2021
dc.descriptionTEXTO COMPLETO EN INGLÉS
dc.description.abstractBackground Psoriasis and periodontitis are immunologically mediated chronic inflammatory diseases. Epidemiologic evidence has linked both; however, the change of markers in gingival crevicular fluid has been poorly evaluated. Objective To evaluate the levels of IL-17A, IL-22, IL-23, S100A7, S100A8, and S100A9 in gingival crevicular fluid of psoriatic and healthy subjects with and without periodontitis and their relations to psoriasis severity. Methods Cross-sectional study. Sample comprised the following groups: healthy controls without periodontitis or with mild periodontitis (n = 21), healthy controls with moderate or severe periodontitis (n = 18), individuals with psoriasis without or mild periodontitis (n = 11), and individuals with psoriasis and moderate or severe periodontitis (n = 32). Levels of IL-17A, IL-22, IL-23, S100A8, and S100A9 were determined by multiplex assay and S100A7 was measured by ELISA. Results No inter-group differences in the levels of IL-17A, IL-22, IL-23, and S100A7 were found. S100A8 levels were higher in psoriatic patients than controls (p < 0.05). S100A8 was positively correlated with psoriasis severity in the group with psoriasis (p < 0.05). S100A9 exceeded the detection limits. Study limitations This pilot study presents a small sample size. Conclusions The concentrations of S100A8 were highest in psoriatic patients regardless of periodontal health/status. S100A8 was associated with the severity of psoriasis. The concentrations of interleukins and S100A7 were similar in psoriatic patients with or without periodontitis vs. healthy controls.
dc.identifier.citationAnais Brasileiros de Dermatologia, Volume 96, Issue 2 , March–April 2021, Pages 163-170
dc.identifier.issn0365-0596
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/60070
dc.language.isoen
dc.publisherSociedade Brasileira de Dermatologia
dc.subjectCytokinesis
dc.subjectPeriodontal diseases
dc.subjectPsoriasis
dc.subjectS100 proteins
dc.titleLevels of the interleukins 17A, 22, and 23 and the S100 protein family in the gingival crevicular fluid of psoriatic patients with or without periodontitis
dc.typeArtículo
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