The vertebrate muscle-specific RING finger protein family includes MuRF4 - A novel, conserved E3-ubiquitin ligase

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dc.contributor.authorMacqueen, Daniel J.
dc.contributor.authorFuentes, Eduardo N.
dc.contributor.authorValdés, Juan Antonio
dc.contributor.authorMolina, Alfredo
dc.contributor.authorMartin, Samuel A.M.
dc.date.accessioned2022-12-28T17:04:09Z
dc.date.available2022-12-28T17:04:09Z
dc.date.issued2014
dc.descriptionIndexación: Scopuses
dc.description.abstractMuscle-specific RING finger (MuRF) proteins are E3-ubiquitin ligases and key regulators of muscle growth and turnover. Here, using a range of phylogenomic approaches, we established the complete-definitive MuRF family of vertebrates. Adding to recognized MuRF1, 2 and 3, we describe a novel family member, hereafter MuRF4, which was independently lost during placental mammal and bird evolution, but is otherwise conserved. MuRF4 transcripts were expressed in heart and skeletal muscles of zebrafish, but were barely detectable in striated muscles of adult anole lizards. We also demonstrate that MuRF1 underwent retrotransposition in the teleost fish ancestor, before the retrogene fully replaced the original gene and muscle-specific function. © 2014 Federation of European Biochemical Societies. All rights reserved.es
dc.description.urihttps://febs-onlinelibrary-wiley-com.recursosbiblioteca.unab.cl/doi/epdf/10.1016/j.febslet.2014.10.008
dc.identifier.doi10.1016/j.febslet.2014.10.008
dc.identifier.issn0014-5793
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/29664
dc.language.isoenes
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectE3-ubiquitin ligasees
dc.subjectEvolutiones
dc.subjectMuscle-specific RING finger familyes
dc.subjectNovel MuRFes
dc.subjectMuRF4es
dc.subjectRetrotranspositiones
dc.subjectStriated musclees
dc.titleThe vertebrate muscle-specific RING finger protein family includes MuRF4 - A novel, conserved E3-ubiquitin ligasees
dc.typeArtículoes
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FEBS Letters - 2014 - Macqueen - The vertebrate muscle‐specific RING finger protein family includes MuRF4 A novel .pdf
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FEBS Letters Volume 588, Issue 23, Pages 4390 - 439728 November 2014
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