Pdgf1aa regulates zebrafish neural crest cells migration through Hif-1 in an oxygen-independent manner

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dc.contributor.authorEspina J.A.
dc.contributor.authorFerrari G.
dc.contributor.authorReyes A.E.
dc.contributor.authorMarchant C.L.
dc.date.accessioned2022-06-25T14:37:12Z
dc.date.available2022-06-25T14:37:12Z
dc.date.issued2018-12
dc.descriptionIndexación Scopuses
dc.description.abstractThe transcription factor Hif-1α regulates epithelial to mesenchymal transition and neural crest cell chemotaxis in Xenopus. Hif-1α is only stabilised under low oxygen levels, and the in vivo stabilisation of this factor in neural crest cells is poorly understood. Multiple oxygen-independent Hif-1α regulators have been described in cell cultures and cancer models. Among these, the PDGF pathway has been linked to neural crest development. The present study established a connection between the Pdgf pathway and Hif-1α stabilisation in zebrafish. Specifically, embryos with a disrupted Pdgf pathway were rescued by employing hif-1α mRNA through qPCR and immunohistochemistry techniques. The data suggest that oxygen levels in the neural crest are normal and that Pdgf1aa regulates neural crest migration through Hif-1α expression. © 2018 Elsevier B.V.es
dc.description.urihttps://www-sciencedirect-com.recursosbiblioteca.unab.cl/science/article/pii/S0925477318300753?via%3Dihub
dc.identifier.citationMechanisms of Development Volume 154, Pages 203 - 207December 2018es
dc.identifier.doi10.1016/j.mod.2018.07.007
dc.identifier.issn09254773
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/22994
dc.language.isoenes
dc.publisherElsevier Ireland Ltdes
dc.subjectPericardiumes
dc.subjectRegenerationes
dc.subjectZebrafishes
dc.titlePdgf1aa regulates zebrafish neural crest cells migration through Hif-1 in an oxygen-independent manneres
dc.typeArtículoes
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