Synthesis and conformational analysis of leptocarpin derivatives. Influence of modification of the oxirane ringon leptocarpin's cytotoxic activity.

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dc.contributor.authorMartínez, Rolando
dc.contributor.authorKesternich, Victor
dc.contributor.authorCarracso, Héctor
dc.contributor.authorÁlvarez-Contreras, Carolina
dc.contributor.author...[et al.].
dc.date.accessioned2014-02-25T13:39:01Z
dc.date.accessioned2016-05-24T20:30:50Z
dc.date.available2014-02-25T13:39:01Z
dc.date.available2016-05-24T20:30:50Z
dc.date.issued2006
dc.descriptionIndexación: Scieloes
dc.description.abstractABSTRACT The reaction in acidconditions of Leptocarpin 1, a compound with antitumor activity, formed two new isomeric products, 8b-angeloyl-1b,3b-dihydroxy-4,10-dimethyl,-D11(13) methylen-4Z,9Z-dieneheliangol-6,12-olide 2 and 8b-angeloyl-1b,3b-dihydroxy-4-methyl-D11(13),D11(14)-dimethylen-4Z-eneheliangol-6,12-olide 3, whose structures reported in this study were established by spectroscopy (1H-NMR, 13C-NMR, MS and IR) and confirmedthrough ROESY experiments and theoretical studies by molecular mechanics. The in vitro cytotoxicity of these isomeric compounds was less active than leptocarpin, showing the importance of the oxirane ring in the biological activity. Cytotoxic activity was measured in six cancer cell lines. Keywords: Conformational analysis; Heliangolide; Sesquiterpene lactones; Cytotoxicity.es
dc.identifier.citationJournal of the Chilean Chemical Society. Vol. 51. N° 4, 2006.es
dc.identifier.issn0717-9707
dc.identifier.otherhttp://dx.doi.org/10.4067/S0717-97072006000400003
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/2366
dc.language.isoenes
dc.publisher2014 Sociedad Chilena de Químicaes
dc.subjectConformational analysis; Heliangolide; Sesquiterpene lactones; Cytotoxicity.es
dc.titleSynthesis and conformational analysis of leptocarpin derivatives. Influence of modification of the oxirane ringon leptocarpin's cytotoxic activity.es
dc.typeArtículoes
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