Improving and measuring the solubility of favipiravir and montelukast in SC-CO2 with ethanol projecting their nanonization
No hay miniatura disponible
Archivos
Fecha
2023-11
Profesor/a Guía
Facultad/escuela
Idioma
en
Título de la revista
ISSN de la revista
Título del volumen
Editor
Royal Society of Chemistry
Nombre de Curso
Licencia CC
https://creativecommons.org/licenses/by-nc/3.0/
Licencia CC
Attribution-NonCommercial 3.0 Unported Deed (CC BY-NC 3.0)
Resumen
Supercritical carbon dioxide (SC-CO2)-based approaches have become more popular in recent years as alternative methods for creating micro- or nanosized medicines. Particularly, high drug solubility is required in those techniques using SC-CO2 as a solvent. During the most recent pandemic years, favipiravir and montelukast were two of the most often prescribed medications for the treatment of COVID-19. In this study, ethanol at 1 and 3 mol% was utilized as a cosolvent to increase the solubility of both medicines in SC-CO2 by a static approach using a range of temperatures (308 to 338 K) and pressure (12 to 30 MPa) values. The experimentally determined solubilities of favipiravir and montelukast in SC-CO2 + 3 mol% ethanol showed solubility values up to 33.3 and 24.5 times higher than that obtained for these drugs with only SC-CO2. The highest values were achieved in the pressure of 12 MPa and temperature of 338 K. Last but not least, six density-based semi-empirical models with various adjustable parameters were used to perform the modeling of the solubility of favipiravir and montelukast. © 2023 The Royal Society of Chemistry.
Notas
Palabras clave
Carbon Dioxide, Drug Delivery, Ethanol, Supercritical Fluid Extraction, Adjustable Parameters, Cosolvents, Density-Based, Drug Solubility, SC CO 2, Semiempirical Models, Solubility Value, Static Approach, Supercritical Carbondioxides
Citación
RSC Advances. Volume 13, Issue 48, Pages 34210 - 34223. 22 November 2023
DOI
10.1039/d3ra05484e