Improving and measuring the solubility of favipiravir and montelukast in SC-CO2 with ethanol projecting their nanonization

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dc.contributor.authorRojas, Adrián
dc.contributor.authorSajadian, Seyed Ali
dc.contributor.authorLópez-De-Dicastillo, Carol
dc.contributor.authorArdestani, Nedasadat Saadati
dc.contributor.authorAguila, Gonzalo
dc.contributor.authorJouyban, Abolghasem
dc.date.accessioned2025-01-15T19:59:38Z
dc.date.available2025-01-15T19:59:38Z
dc.date.issued2023-11
dc.description.abstractSupercritical carbon dioxide (SC-CO2)-based approaches have become more popular in recent years as alternative methods for creating micro- or nanosized medicines. Particularly, high drug solubility is required in those techniques using SC-CO2 as a solvent. During the most recent pandemic years, favipiravir and montelukast were two of the most often prescribed medications for the treatment of COVID-19. In this study, ethanol at 1 and 3 mol% was utilized as a cosolvent to increase the solubility of both medicines in SC-CO2 by a static approach using a range of temperatures (308 to 338 K) and pressure (12 to 30 MPa) values. The experimentally determined solubilities of favipiravir and montelukast in SC-CO2 + 3 mol% ethanol showed solubility values up to 33.3 and 24.5 times higher than that obtained for these drugs with only SC-CO2. The highest values were achieved in the pressure of 12 MPa and temperature of 338 K. Last but not least, six density-based semi-empirical models with various adjustable parameters were used to perform the modeling of the solubility of favipiravir and montelukast. © 2023 The Royal Society of Chemistry.
dc.description.urihttps://pubs.rsc.org/en/content/articlelanding/2023/ra/d3ra05484e
dc.identifier.citationRSC Advances. Volume 13, Issue 48, Pages 34210 - 34223. 22 November 2023
dc.identifier.doi10.1039/d3ra05484e
dc.identifier.issn2046-2069
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/63030
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.rights.licensehttps://creativecommons.org/licenses/by-nc/3.0/
dc.rights.uriAttribution-NonCommercial 3.0 Unported Deed (CC BY-NC 3.0)
dc.subjectCarbon Dioxide
dc.subjectDrug Delivery
dc.subjectEthanol
dc.subjectSupercritical Fluid Extraction
dc.subjectAdjustable Parameters
dc.subjectCosolvents
dc.subjectDensity-Based
dc.subjectDrug Solubility
dc.subjectSC CO 2
dc.subjectSemiempirical Models
dc.subjectSolubility Value
dc.subjectStatic Approach
dc.subjectSupercritical Carbondioxides
dc.titleImproving and measuring the solubility of favipiravir and montelukast in SC-CO2 with ethanol projecting their nanonization
dc.typeArtículo
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