Synthesis and in vitro growth inhibition of 2-allylphenol derivatives against Phythopthora cinnamomi rands

Vista sencilla de ítem
dc.contributor.authorOlea, Andrés F.
dc.contributor.authorEspinoza, Luis
dc.contributor.authorSedan, Claudia
dc.contributor.authorThomas, Mario
dc.contributor.authorMartínez, Rolando
dc.contributor.authorMellado, Marco
dc.contributor.authorCarrasco, Héctor
dc.contributor.authorDíaz, Katy
dc.date.accessioned2021-11-09T15:42:57Z
dc.date.available2021-11-09T15:42:57Z
dc.date.issued2019-11
dc.descriptionIndexación: Scopuses
dc.description.abstractPhytophthora cinnamomi is a phytopathogen that causes extensive damage in different crops, and therefore, produces important economic losses all around the world. Chemical fungicides are a key factor for the control of this disease. However, ecological and environmental considerations, as well as the appearance of strains that are resistant to commercial fungicides, have prompted the quest for new antifungal agents which are of low ecological impact. In this work, a series of new 2-allylphenol derivatives was synthesized, and their structures were confirmed by FT-IR, NMR, and MS. Some of the synthesized compounds, more specifically nitro derivatives, exhibit strong growth inhibition of P. cinnamomi with EC50 as low as 10.0 μg/mL. This level of activity is similar to that exhibited by METALAXYL MZ 58 WP, a commonly-used commercial fungicide; therefore, these compounds might be of agricultural interest due to their potential use as fungicides against P. cinnamomi. The results indicate that this activity depends on the chemical structures of the 2-allylphenol derivatives, and that it is strongly enhanced in molecules where nitro and hydroxyl groups adopt a -para configuration. These effects are discussed in terms of the electronic distribution of the aromatic ring induced by substituent groups. © 2019 by the authors.es
dc.description.urihttps://www.mdpi.com/1420-3049/24/22/4196/htm
dc.identifier.citationMolecules Volume 24, Issue 2219 November 2019 Article number 4196es
dc.identifier.doi10.3390/molecules24224196
dc.identifier.issn1420-3049
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/20810
dc.language.isoenes
dc.publisherMDPI AGes
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subject2-allylphenoles
dc.subjectFungicidees
dc.subjectPest controles
dc.subjectPhytophthora cinnamomies
dc.subjectStructure-activity relationshipes
dc.titleSynthesis and in vitro growth inhibition of 2-allylphenol derivatives against Phythopthora cinnamomi randses
dc.typeArtículoes
Archivos
Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
molecules-24-04196.pdf
Tamaño:
1.12 MB
Formato:
Adobe Portable Document Format
Descripción:
TEXTO COMPLETO EN INGLES
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
FCE - Artículos de Revista