Chlorin e6-Conjugated Mesoporous Titania Nanorods as Potential Nanoplatform for Photo-Chemotherapy

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dc.contributor.authorVélez-Peña, Estefanía
dc.contributor.authorJiménez, Verónica A.
dc.contributor.authorManzo-Merino, Joaquín
dc.contributor.authorAlderete, Joel B.
dc.contributor.authorCampos, Cristian H.
dc.date.accessioned2024-07-09T19:24:17Z
dc.date.available2024-07-09T19:24:17Z
dc.date.issued2024-06
dc.descriptionIndexación: Scopus.
dc.description.abstractPhotodynamic therapy (PDT) has developed as an efficient strategy for cancer treatment. PDT involves the production of reactive oxygen species (ROS) by light irradiation after activating a photosensitizer (PS) in the presence of O2. PS-coupled nanomaterials offer additional advantages, as they can merge the effects of PDT with conventional enabling-combined photo-chemotherapeutics effects. In this work, mesoporous titania nanorods were surface-immobilized with Chlorin e6 (Ce6) conjugated through 3-(aminopropyl)-trimethoxysilane as a coupling agent. The mesoporous nanorods act as nano vehicles for doxorubicin delivery, and the Ce6 provides a visible light-responsive production of ROS to induce PDT. The nanomaterials were characterized by XRD, DRS, FTIR, TGA, N2 adsorption–desorption isotherms at 77 K, and TEM. The obtained materials were tested for their singlet oxygen and hydroxyl radical generation capacity using fluorescence assays. In vitro cell viability experiments with HeLa cells showed that the prepared materials are not cytotoxic in the dark, and that they exhibit photodynamic activity when irradiated with LED light (150 W m−2). Drug-loading experiments with doxorubicin (DOX) as a model chemotherapeutic drug showed that the nanostructures efficiently encapsulated DOX. The DOX-nanomaterial formulations show chemo-cytotoxic effects on Hela cells. Combined photo-chemotoxicity experiments show enhanced effects on HeLa cell viability, indicating that the conjugated nanorods are promising for use in combined therapy driven by LED light irradiation.
dc.description.urihttps://www-scopus-com.recursosbiblioteca.unab.cl/record/display.uri?eid=2-s2.0-85195894435&origin=resultslist&sort=plf-f&src=s&nlo=&nlr=&nls=&sid=db41dc2dbb1a468594f6f9b09ff1ccd6&sot=aff&sdt=cl&cluster=scofreetoread%2c%22all%22%2ct&sl=61&s=AF-ID%28%22Universidad+Andr%c3%a9s+Bello%22+60002636%29+AND+SUBJAREA%28MATE%29&relpos=2&citeCnt=0&searchTerm=
dc.identifier.citationNanomaterials Open Access Volume 14, Issue 11 June 2024 Article number 933
dc.identifier.doi10.3390/nano14110933
dc.identifier.issn20794991
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/58379
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.rights.licenseCC BY 4.0 ATTRIBUTION 4.0 INTERNATIONAL
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectChlorin e6
dc.subjectcombined therapy
dc.subjectmesoporous titania nanorods
dc.subjectphotodynamic therapy
dc.titleChlorin e6-Conjugated Mesoporous Titania Nanorods as Potential Nanoplatform for Photo-Chemotherapy
dc.typeArtículo
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