Peptides and proteins used to enhance gold nanoparticle delivery to the brain: Preclinical approaches

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dc.contributor.authorVelasco-Aguirre, Carolina
dc.contributor.authorMorales, Francisco
dc.contributor.authorGallardo-Toledo, Eduardo
dc.contributor.authorGuerrero, Simon
dc.contributor.authorGiralt, Ernest
dc.contributor.authorAraya, Eyleen
dc.contributor.authorKogan, Marcelo J.
dc.date.accessioned2023-03-24T13:55:41Z
dc.date.available2023-03-24T13:55:41Z
dc.date.issued2015-08
dc.descriptionIndexación: Scopuses
dc.description.abstractAn exciting and emerging field in nanomedicine involves the use of gold nanoparticles (AuNPs) in the preclinical development of new strategies for the treatment and diagnosis of brain-related diseases such as neurodegeneration and cerebral tumors. The treatment of many brain-related disorders with AuNPs, which possess useful physical properties, is limited by the blood–brain barrier (BBB). The BBB highly regulates the substances that can permeate into the brain. Peptides and proteins may represent promising tools to improve the delivery of AuNPs to the central nervous system (CNS). In this review, we summarize the potential applications of AuNPs to CNS disorders, discuss different strategies based on the use of peptides or proteins to improve the delivery of AuNPs to the brain, and examine the intranasal administration route, which bypasses the BBB. We also analyze the potential neurotoxicity of AuNPs and the perspectives and new challenges concerning the use of peptides and proteins to enhance the delivery of AuNPs to the brain. The majority of the work described in this review is in a preclinical stage of experimentation, or in select cases, in clinical trials in humans. We note that the use of AuNPs still requires substantial study before being translated into human applications. However, for further clinical research, the issues related to the potential use of AuNPs must be analyzed. © 2015 Velasco-Aguirre et al.es
dc.description.urihttps://www.dovepress.com/peptides-and-proteins-used-to-enhance-gold-nanoparticle-delivery-to-th-peer-reviewed-fulltext-article-IJN
dc.identifier.citationInternational Journal of Nanomedicine Volume 10, Pages 4919 - 493610 August 2015es
dc.identifier.doi10.2147/IJN.S82310
dc.identifier.issn1176-9114
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/47851
dc.language.isoenes
dc.publisherDove Medical Press Ltd.es
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectBiodistributiones
dc.subjectBlood–brain barrieres
dc.subjectCentral nervous systemes
dc.subjectDrug deliveryes
dc.subjectEPR effectes
dc.subjectTranscytosises
dc.titlePeptides and proteins used to enhance gold nanoparticle delivery to the brain: Preclinical approacheses
dc.typeArtículoes
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