Identification of the Transcriptional Regulatory Role of RUNX2 by Network Analysis in Lung Cancer Cells

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dc.contributor.authorOtálora-Otálora, Beatriz Andrea
dc.contributor.authorGonzález Prieto, Cristian
dc.contributor.authorGuerrero, Lucia
dc.contributor.authorBernal-Forigua, Camila
dc.contributor.authorMontecino, Martin
dc.contributor.authorCañas, Alejandra
dc.contributor.authorLópez-Kleine, Liliana
dc.contributor.authorRojas, Adriana
dc.date.accessioned2023-03-29T18:10:07Z
dc.date.available2023-03-29T18:10:07Z
dc.date.issued2022-10
dc.descriptionIndexación: Scopuses
dc.description.abstractThe use of a new bioinformatics pipeline allowed the identification of deregulated transcription factors (TFs) coexpressed in lung cancer that could become biomarkers of tumor establishment and progression. A gene regulatory network (GRN) of lung cancer was created with the normalized gene expression levels of differentially expressed genes (DEGs) from the microarray dataset GSE19804. Moreover, coregulatory and transcriptional regulatory network (TRN) analyses were performed for the main regulators identified in the GRN analysis. The gene targets and binding motifs of all potentially implicated regulators were identified in the TRN and with multiple alignments of the TFs’ target gene sequences. Six transcription factors (E2F3, FHL2, ETS1, KAT6B, TWIST1, and RUNX2) were identified in the GRN as essential regulators of gene expression in non-small-cell lung cancer (NSCLC) and related to the lung tumoral process. Our findings indicate that RUNX2 could be an important regulator of the lung cancer GRN through the formation of coregulatory complexes with other TFs related to the establishment and progression of lung cancer. Therefore, RUNX2 could become an essential biomarker for developing diagnostic tools and specific treatments against tumoral diseases in the lung after the experimental validation of its regulatory function.es
dc.description.urihttps://www.mdpi.com/2227-9059/10/12/3122
dc.identifier.doihttps://doi.org/10.3390/biomedicines10123122
dc.identifier.issn2227-9059
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/48030
dc.language.isoenes
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectlung cancer (LC)es
dc.subjectdifferentially expressed genes (DEGs)es
dc.subjecttranscription factors (TFs)es
dc.subjectcoexpression networkses
dc.subjectgene regulatory network (GRN)es
dc.subjectdiagnostic and prognostic biomarkerses
dc.titleIdentification of the Transcriptional Regulatory Role of RUNX2 by Network Analysis in Lung Cancer Cellses
dc.typeArtículoes
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